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Gene Review:

traT - conjugal transfer surface exclusion...

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Rotger, R. et al., Sukupolvi, S. et al.

Rotger, Casadesús,

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Disease relevance of traT

The nucleotide sequence of the traT gene present in the virulence-associated plasmid of Salmonella typhimurium was determined [1].

High impact information on traT

A mutation leading to increased permeability of the outer membrane to hydrophobic agents, previously localized to the traT gene, was shown to change a glycine residue to arginine within one of these hydrophobic regions [1].
Other loci of the plasmid, such as the fimbrial operon pef, the conjugal transfer gene traT and the enigmatic rck and rsk loci, may play a role in other stages of the infection process [2].

References

Characterization of the traT gene and mutants that increase outer membrane permeability from the Salmonella typhimurium virulence plasmid. Sukupolvi, S., Vuorio, R., Qi, S.Y., O'Connor, D., Rhen, M. Mol. Microbiol. (1990) [Pubmed]
The virulence plasmids of Salmonella. Rotger, R., Casadesús, J. Int. Microbiol. (1999) [Pubmed]

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