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Gene Review:

spvC - hydrophilic protein

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Ginocchio, C.C. et al., Boyd, E.F. et al., Abouzeed, Y.M. et al., Matsui, H. et al., Krause, M. et al.

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Disease relevance of spvC

Analysis of the phylogenetic distribution of spv among Salmonella isolates and comparative nucleotide sequence analysis of spvA and spvC suggests that the spv region was acquired very recently, after speciation of the salmonellae [1].

High impact information on spvC

The predicted overall secondary structures of these proteins show significant similarities and indicate a modular construction with a hydrophobic amino-terminal half, consisting of six to eight potential transmembrane domains, and a hydrophilic carboxy terminus which is predicted to reside in the cytoplasm [2].
A point mutation in the spvBC plasmid preventing translation but not transcription of spvC eliminated the ability of the plasmid to confer virulence [3].
Deletion of a 320-bp EcoRI-ApaI segment that contains both start sites abolished expression of the downstream spvB and spvC genes [4].
All but 3 of the spvC-positive isolates possessed a 90 kilobasepair (kbp) plasmid suggesting that the 3 isolates had the spvC gene on their chromosome [5].

References

Salmonella virulence plasmid. Modular acquisition of the spv virulence region by an F-plasmid in Salmonella enterica subspecies I and insertion into the chromosome of subspecies II, IIIa, IV and VII isolates. Boyd, E.F., Hartl, D.L. Genetics (1998) [Pubmed]
Functional conservation among members of the Salmonella typhimurium InvA family of proteins. Ginocchio, C.C., Galán, J.E. Infect. Immun. (1995) [Pubmed]
Virulence plasmid-borne spvB and spvC genes can replace the 90-kilobase plasmid in conferring virulence to Salmonella enterica serovar Typhimurium in subcutaneously inoculated mice. Matsui, H., Bacot, C.M., Garlington, W.A., Doyle, T.J., Roberts, S., Gulig, P.A. J. Bacteriol. (2001) [Pubmed]
Regulation of plasmid virulence gene expression in Salmonella dublin involves an unusual operon structure. Krause, M., Fang, F.C., Guiney, D.G. J. Bacteriol. (1992) [Pubmed]
Characterization of Salmonella isolates from beef cattle, broiler chickens and human sources on Prince Edward Island. Abouzeed, Y.M., Hariharan, H., Poppe, C., Kibenge, F.S. Comp. Immunol. Microbiol. Infect. Dis. (2000) [Pubmed]

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