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Gene Review:

P4p04 - int gene product (AA 1-440)

Enterobacteria phage P4

Calì, S. et al., Ramsay, J.P. et al., Pierson, L.S. et al., Sullivan, J.T. et al., Piazzolla, D. et al.

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Disease relevance of P4p04

One would be recognized by Escherichia coli RNA polymerase and may be repressed by integrase protein [1].
The element is 500 kb in size, integrates into a phe-tRNA gene, and encodes an integrase of the phage P4 family just within its left end [2].

High impact information on P4p04

Excision and transfer of the Mesorhizobium loti R7A symbiosis island requires an integrase IntS, a novel recombination directionality factor RdfS, and a putative relaxase RlxS [3].
A 1.3 x 10(3) base open reading frame codes for P4 integrase [1].
Phage P4 int gene encodes the integrase responsible for phage integration into and excision from the Escherichia coli chromosome [4].
Upon infection of its host Escherichia coli, satellite bacteriophage P4 can integrate its genome into the bacterial chromosome by Int-mediated site-specific recombination between the attP and the attB sites [5].

References

Integration of satellite bacteriophage P4 in Escherichia coli. DNA sequences of the phage and host regions involved in site-specific recombination. Pierson, L.S., Kahn, M.L. J. Mol. Biol. (1987) [Pubmed]
Evolution of rhizobia by acquisition of a 500-kb symbiosis island that integrates into a phe-tRNA gene. Sullivan, J.T., Ronson, C.W. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
Excision and transfer of the Mesorhizobium loti R7A symbiosis island requires an integrase IntS, a novel recombination directionality factor RdfS, and a putative relaxase RlxS. Ramsay, J.P., Sullivan, J.T., Stuart, G.S., Lamont, I.L., Ronson, C.W. Mol. Microbiol. (2006) [Pubmed]
Expression of phage P4 integrase is regulated negatively by both Int and Vis. Piazzolla, D., Calì, S., Spoldi, E., Forti, F., Sala, C., Magnoni, F., Dehò, G., Ghisotti, D. J. Gen. Virol. (2006) [Pubmed]
Bacteriophage P4 Vis protein is needed for prophage excision. Calì, S., Spoldi, E., Piazzolla, D., Dodd, I.B., Forti, F., Dehò, G., Ghisotti, D. Virology (2004) [Pubmed]

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