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Gene Review:

merD - merD

Shigella flexneri 2b

Griffin, H.G. et al., Misra, T.K. et al., Ni'Bhriain, N.N. et al., Bhriain, N.N. et al.

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High impact information on merD

This region included the 3'-terminal part of the merA gene, merD, unidentified reading frame URF1, and a part of URF2 homologous to previously sequenced determinants of plasmid R100 [1].
The products of the merR and merD genes were not identified [2].
The nucleotide sequence for the 2240 bp of plasmid R100 following the merC gene of the mercuric resistance operon has been determined and compared with the homologous sequence of transposon Tn501 [3].
Evidence was obtained for two new mer genes, which have been called merC and merD [4].

Biological context of merD

Between the merA and merD genes, an open reading frame encoding a 212 amino acid polypeptide was identified as the merB gene that determines the enzyme organomercurial lyase that cleaves the C--Hg bond of phenylmercury [1].

References

Cloning and DNA sequence of the mercuric- and organomercurial-resistance determinants of plasmid pDU1358. Griffin, H.G., Foster, T.J., Silver, S., Misra, T.K. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
Polypeptides specified by the mercuric resistance (mer) operon of plasmid R100. Bhriain, N.N., Foster, T.J. Gene (1986) [Pubmed]
Mercuric reductase structural genes from plasmid R100 and transposon Tn501: functional domains of the enzyme. Misra, T.K., Brown, N.L., Haberstroh, L., Schmidt, A., Goddette, D., Silver, S. Gene (1985) [Pubmed]
Tn5 insertion mutations in the mercuric ion resistance genes derived from plasmid R100. Ni'Bhriain, N.N., Silver, S., Foster, T.J. J. Bacteriol. (1983) [Pubmed]

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