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Chemical Compound Review

Phenylmercury     phenylmercury

Synonyms: SureCN113384, AG-G-13494, CHEBI:49819, CTK0E6684, AR-1L0640, ...
 
 
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Disease relevance of phenylmercury

  • The merG gene product is involved in phenylmercury resistance in Pseudomonas strain K-62 [1].
  • When the merG gene in a compatible plasmid was transformed into the E. coli strain carrying pMU29, the high uptake of and high sensitivity to phenylmercury were almost completely restored to their original levels [1].
  • One recombinant plasmid (pMRA17) inducibly encoded a typical broad-spectrum mercurial resistance, whereas the other recombinant plasmid (pMRB01) constitutively conferred hypersensitivity to phenylmercury in the absence of mercuric reductase activity [2].
 

High impact information on phenylmercury

  • Between the merA and merD genes, an open reading frame encoding a 212 amino acid polypeptide was identified as the merB gene that determines the enzyme organomercurial lyase that cleaves the C--Hg bond of phenylmercury [3].
  • The interactions of inorganic mercury Hg(II), methylmercury (MeHg(I)), ethylmercury (EtHg(I)), and phenylmercury (PhHg(I)) with DNA have been probed by capillary electrophoresis with on-line electrothermal atomic absorption spectrometric detection (CE-ETAAS) in combination with circular dichroism and Fourier transform infrared spectroscopy [4].
  • Capillary electrophoretic separation of four mercury species (inorganic Hg(2+), methyl-, ethyl-, and phenylmercury) was achieved in less than 8 min with an electrolyte consisting of 150 mM 2-amino-2-methyl-propanol (AMP) at pH 11 [5].
  • Escherichia coli cells bearing pMU29, which carries a deletion of the merG gene, took up significantly more phenylmercury than the bacteria with the intact plasmid pMRA17 [1].
  • Deletion of the merG gene from the broad-spectrum mer operon of pMR26 had no effect on the inorganic mercury resistance phenotype, but rendered the bacterium more sensitive to phenylmercury than its isogenic wild-type strain [1].
 

Biological context of phenylmercury

 

Anatomical context of phenylmercury

 

Gene context of phenylmercury

 

Analytical, diagnostic and therapeutic context of phenylmercury

References

  1. The merG gene product is involved in phenylmercury resistance in Pseudomonas strain K-62. Kiyono, M., Pan-Hou, H. J. Bacteriol. (1999) [Pubmed]
  2. Organomercurial resistance determinants in Pseudomonas K-62 are present on two plasmids. Kiyono, M., Omura, T., Fujimori, H., Pan-Hou, H. Arch. Microbiol. (1995) [Pubmed]
  3. Cloning and DNA sequence of the mercuric- and organomercurial-resistance determinants of plasmid pDU1358. Griffin, H.G., Foster, T.J., Silver, S., Misra, T.K. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  4. Probing mercury species-DNA interactions by capillary electrophoresis with on-line electrothermal atomic absorption spectrometric detection. Li, Y., Jiang, Y., Yan, X.P. Anal. Chem. (2006) [Pubmed]
  5. Ion exchange preconcentration and separation of mercury species by CE with indirect contactless conductometric detection. Houserov??, P., Kub??n, P., Kub??n, V. Electrophoresis (2006) [Pubmed]
  6. Role of MerT and MerP from Pseudomonas K-62 plasmid pMR26 in the transport of phenylmercury. Kiyono, M., Uno, Y., Omura, T., Pan-Hou, H. Biol. Pharm. Bull. (2000) [Pubmed]
  7. Mercury operon regulation by the merR gene of the organomercurial resistance system of plasmid pDU1358. Nucifora, G., Chu, L., Silver, S., Misra, T.K. J. Bacteriol. (1989) [Pubmed]
  8. Mercury-specific lymphocytes: an indication of mercury allergy in man. Stejskal, V.D., Forsbeck, M., Cederbrant, K.E., Asteman, O. J. Clin. Immunol. (1996) [Pubmed]
  9. Assay of phenylmercury salts in pharmaceutical products by high-performance liquid chromatography of the morpholinedithiocarbamate derivative. Parkin, J.E. J. Chromatogr. (1987) [Pubmed]
  10. Selective isolation of newly synthesized mammalian mRNA after in vivo labeling with 4-thiouridine or 6-thioguanosine. Woodford, T.A., Schlegel, R., Pardee, A.B. Anal. Biochem. (1988) [Pubmed]
 
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