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Gene Review:

SRPN2 - AGAP006911-PA

Anopheles gambiae str. PEST

Michel, K. et al.

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High impact information on SRPN2

Importantly, we tested whether the absence of SRPN2 from the hemolymph influences Plasmodium falciparum development [1].
Using a reverse genetics approach, we studied the effect of SRPN2 on melanization in An. gambiae adult females in vivo [1].
As reported, the knockdown of SRPN2 adversely affects the ability of the rodent malaria parasite Plasmodium berghei to invade the midgut epithelium and develop into oocysts [1].

Anatomical context of SRPN2

Depletion of SRPN2 from the mosquito hemolymph increases melanin deposition on foreign surfaces such as negatively charged Sephadex beads [1].

References

Increased melanizing activity in Anopheles gambiae does not affect development of Plasmodium falciparum. Michel, K., Suwanchaichinda, C., Morlais, I., Lambrechts, L., Cohuet, A., Awono-Ambene, P.H., Simard, F., Fontenille, D., Kanost, M.R., Kafatos, F.C. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]

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