Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

DMBX1 - diencephalon/mesencephalon homeobox 1

Homo sapiens

Synonyms: Diencephalon/mesencephalon homeobox protein 1, MBX, OTX3, Orthodenticle homolog 3, PAXB, ...

Meunier, F.A. et al., Ohtoshi, A. et al.

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High impact information on DMBX1

Linkage analysis mapped mouse Dmbx1 to the mid-portion of chromosome 4 that is the homologous gene cluster region of human chromosome 1, where human DMBX1 is located [1].
8. OTX-3 is a novel type of sodium-channel activating toxin that discriminates between nerve and skeletal muscle membranes [2].
4. Extracellular recording of compound action potentials revealed that OTX-3 affected neither excitability nor conduction along intramuscular nerve branches [2].
2. OTX-3 (1-10 microg ml(-1)) applied to cutaneous pectoris nerve-muscle preparations depolarized skeletal muscle fibres and caused spontaneous contractions [2].

References

Dmbx1, a novel evolutionarily conserved paired-like homeobox gene expressed in the brain of mouse embryos. Ohtoshi, A., Nishijima, I., Justice, M.J., Behringer, R.R. Mech. Dev. (2002) [Pubmed]
Selective depolarization of the muscle membrane in frog nerve-muscle preparations by a chromatographically purified extract of the dinoflagellate Ostreopsis lenticularis. Meunier, F.A., Mercado, J.A., Molgó, J., Tosteson, T.R., Escalona de Motta, G. Br. J. Pharmacol. (1997) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

dmbx1b	Danio rerio
DMBX1	Gallus gallus
DMBX1	Macaca mulatta
Dmbx1	Mus musculus
Dmbx1	Rattus norvegicus
LOC100493907	Xenopus (Silurana) tropicalis

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