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Gene Review

Dmbx1  -  diencephalon/mesencephalon homeobox 1

Mus musculus

Synonyms: Atx, Cdmx, Diencephalon/mesencephalon homeobox protein 1, Diencephalon/mesencephalon-expressed brain homeobox gene 1 protein, Mbx, ...
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Disease relevance of Dmbx1

  • Neonatal lethality, dwarfism, and abnormal brain development in Dmbx1 mutant mice [1].

High impact information on Dmbx1


Biological context of Dmbx1


Anatomical context of Dmbx1


Regulatory relationships of Dmbx1

  • These data suggest that Otx3/Dmbx1 represses Otx2-mediated transcription in the developing brain [3].

Other interactions of Dmbx1

  • Dmbx1 shares its caudal border of expression with Otx2, while expression is sharply delimited rostrally by the synencephalic-parencephalic boundary, later becoming restricted to the posterior synencephalon [4].
  • We have isolated a paired homeobox containing gene, which has been recently named Dmbx1 (Mech. Dev. 110 (2002) 241) [7].

Analytical, diagnostic and therapeutic context of Dmbx1

  • Whole-mount in situ hybridization revealed that Dmbx1 expression is detected in 7.5-9.5 dpc mouse embryos [5].
  • Otx3 mRNA was expressed in mouse embryos from 10.5 to 13.5 days postcoitum (dpc) and in adult cerebellum as assessed by Northern blotting [2].


  1. Neonatal lethality, dwarfism, and abnormal brain development in Dmbx1 mutant mice. Ohtoshi, A., Behringer, R.R. Mol. Cell. Biol. (2004) [Pubmed]
  2. Identification, tissue expression, and functional characterization of Otx3, a novel member of the Otx family. Zhang, Y., Miki, T., Iwanaga, T., Koseki, Y., Okuno, M., Sunaga, Y., Ozaki, N., Yano, H., Koseki, H., Seino, S. J. Biol. Chem. (2002) [Pubmed]
  3. Functional analysis of transcriptional repressor Otx3/Dmbx1. Kimura, K., Miki, T., Shibasaki, T., Zhang, Y., Ogawa, M., Saisho, H., Okuno, M., Iwanaga, T., Seino, S. FEBS Lett. (2005) [Pubmed]
  4. The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum. Gogoi, R.N., Schubert, F.R., Martinez-Barbera, J.P., Acampora, D., Simeone, A., Lumsden, A. Mech. Dev. (2002) [Pubmed]
  5. Dmbx1, a novel evolutionarily conserved paired-like homeobox gene expressed in the brain of mouse embryos. Ohtoshi, A., Nishijima, I., Justice, M.J., Behringer, R.R. Mech. Dev. (2002) [Pubmed]
  6. Generation and maintenance of Dmbx1 gene-targeted mutant alleles. Ohtoshi, A., Bradley, A., Behringer, R.R., Nishijima, I. Mamm. Genome (2006) [Pubmed]
  7. Dmbx1 is a paired-box containing gene specifically expressed in the caudal most brain structures. Broccoli, V., Colombo, E., Cossu, G. Mech. Dev. (2002) [Pubmed]
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