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Gene Review:

Coch - coagulation factor C homolog (Limulus...

Mus musculus

Synonyms: AW122937, COCH-5B2, Coch-5B2, Cochlin, D12H14S564E

Rodriguez, C.I. et al., Makishima, T. et al., Solares, C.A. et al., Ikezono, T. et al.

Ikezono, Omori, Ichinose, Pawankar, Watanabe, Yagi,

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Disease relevance of Coch

Five weeks after immunization of SWXJ mice with either Coch 131-150 or beta-tectorin 71-90, auditory brainstem responses (ABR) showed significant hearing loss at all frequencies tested [1].

High impact information on Coch

Coch is also highly expressed in other tissues, including the spleen and inner ear, but only in the uterus is Coch expression regulated by LIF [2].
Treatment of LE with LIF, both in vitro and in vivo, resulted in the up-regulation of Coch [2].
In mice carrying the tagged Coch gene, expression of Coch was detected in the LE and also at the site of embryo implantation [2].
Although loss of Coch expression is not essential to reproduction in mice, it may serve as a useful marker for assessing the state of uterine receptivity in response to LIF at the onset of implantation [2].
Homozygous Coch (-/-) mice express no detectable cochlin in the inner ear [3].

Biological context of Coch

Auditory brainstem responses to click and pure-tone stimuli (8, 16, 32 kHz) were indistinguishable among wild type and homozygous Coch (-/-) mice [3].
Here, we have characterized the auditory phenotype associated with a genomic deletion of mouse Coch downstream of the LCCL domain [3].

Anatomical context of Coch

The Coch protein constitutes 70% of bovine inner ear proteins and is composed of 16 different protein spots, with charge and size heterogeneity [4].
A Coch-LacZDeltaneo reporter allele detected Coch mRNA expression in nonsensory epithelial and stromal regions of the cochlea and vestibular labyrinth [3].
Coch mRNA localized to the LE of wild-type mice and was not detected in uteri from Lif-deficient mice [2].

References

Murine autoimmune hearing loss mediated by CD4+ T cells specific for inner ear peptides. Solares, C.A., Edling, A.E., Johnson, J.M., Baek, M.J., Hirose, K., Hughes, G.B., Tuohy, V.K. J. Clin. Invest. (2004) [Pubmed]
Cochlin, a secreted von Willebrand factor type a domain-containing factor, is regulated by leukemia inhibitory factor in the uterus at the time of embryo implantation. Rodriguez, C.I., Cheng, J.G., Liu, L., Stewart, C.L. Endocrinology (2004) [Pubmed]
Targeted disruption of mouse Coch provides functional evidence that DFNA9 hearing loss is not a COCH haploinsufficiency disorder. Makishima, T., Rodriguez, C.I., Robertson, N.G., Morton, C.C., Stewart, C.L., Griffith, A.J. Hum. Genet. (2005) [Pubmed]
Identification of the protein product of the Coch gene (hereditary deafness gene) as the major component of bovine inner ear protein. Ikezono, T., Omori, A., Ichinose, S., Pawankar, R., Watanabe, A., Yagi, T. Biochim. Biophys. Acta (2001) [Pubmed]

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