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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Cox17  -  cytochrome c oxidase assembly protein 17

Mus musculus

Synonyms: AI037035, COX17, Cox17a, Cytochrome c oxidase copper chaperone
 
 
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High impact information on Cox17

  • Although the COX17 gene was previously mapped to chromosome 13q14-21, our results suggest that a COX17 pseudogene maps to this region [1].
  • Immunocytochemical analysis showed that Cox17p immunoreactivity was strong in the pituitary cell line, AtT-20 [2].
  • These findings suggested that Cox17p is not only part of the respiratory chain but also involved in brain and endocrine functions [2].
 

Biological context of Cox17

 

Analytical, diagnostic and therapeutic context of Cox17

  • To investigate the physiological function of Cox17p in mammals, we performed Northern blot analysis using probes containing the mouse and rat sequences obtained by RT-PCR [2].

References

  1. Characterization and localization of human COX17, a gene involved in mitochondrial copper transport. Punter, F.A., Adams, D.L., Glerum, D.M. Hum. Genet. (2000) [Pubmed]
  2. The expression of Cox17p in rodent tissues and cells. Kako, K., Tsumori, K., Ohmasa, Y., Takahashi, Y., Munekata, E. Eur. J. Biochem. (2000) [Pubmed]
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