The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Crygf  -  crystallin, gamma F

Mus musculus

Synonyms: 3110001K11Rik, Cryg-2, DGcry-2, Gamma-F-crystallin, Gamma-crystallin F, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Crygf

 

High impact information on Crygf

  • This result is supported by the functional analysis of corresponding expression constructs in cell culture, where the Aey11 and Aey18 alleles did not show a stimulation of the Six3 promotor or an inhibition of the Crygf promoter (as wild-type constructs do) [2].
  • A T-->A exchange in exon 2 of the Crygf gene leads to a Val-->Glu exchange in codon 38 and was considered to be causative for the cataract phenotype; therefore, Crygf(Rop) has been suggested as the designation for the mutation [1].
 

Biological context of Crygf

  • Reporter gene analysis used Crygf and Six3 promoter fragments in front of a luciferase gene and HEK293 cells as recipients [2].

References

  1. Crygf(Rop): the first mutation in the Crygf gene causing a unique radial lens opacity. Graw, J., Klopp, N., Neuhäuser-Klaus, A., Favor, J., Löster, J. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  2. Three novel Pax6 alleles in the mouse leading to the same small-eye phenotype caused by different consequences at target promoters. Graw, J., Löster, J., Puk, O., Münster, D., Haubst, N., Soewarto, D., Fuchs, H., Meyer, B., Nürnberg, P., Pretsch, W., Selby, P., Favor, J., Wolf, E., Hrabé de Angelis, M. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
 
WikiGenes - Universities