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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Cryge  -  crystallin, gamma E

Mus musculus

Synonyms: Cryg-2, Cryg-6, DGcry-2, Elo, Gamma-E-crystallin, ...
 
 
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Disease relevance of Cryge

  • However, DNA walking identified a murine endogenous retrovirus (IAPLTR1: ERVK) insertion in exon 3 of Cryge, disrupting the coding sequence for gammaE-crystallin [1].
 

High impact information on Cryge

  • In addition, the mutant mRNA is present in the affected lens, providing further support for our hypothesis that the deletion is responsible for the dominant Elo phenotype [2].
  • The murine Elo (eye lens obsolescence) mutation confers a dominant phenotype characterized by malformation of the eye lens [2].
  • A frameshift mutation in the gamma E-crystallin gene of the Elo mouse [2].
  • Two mutations occur at the same site in the Crygd and Cryge genes (Leu45-->Pro) [3].
  • However, another open reading frame was observed just 19 bp downstream of the regular Cryge start codon, resulting in a protein of 119 amino acids and a calculated molecular weight of 13 kD [4].
 

Biological context of Cryge

  • An A --> G exchange in the middle of intron 1 of the Cryge gene was found as the only alteration cosegregating with the cataractous phenotype [5].
  • Close linkage of the dominant cataract mutations (Cat-2) with Idh-1 and cryge on mouse chromosome 1 [6].
 

Anatomical context of Cryge

  • In addition, the previously known mutant eye lens obsolescence, Elo, maps to the same point [7].
  • We investigated murine CRYGE/f promoters of different length in lens epithelial cell lines [8].
  • Defect of a fiber cell-specific 94-kDa protein in the lens of inherited microphthalmic mutant mouse Elo [9].
 

Associations of Cryge with chemical compounds

  • From linkage analyses of the three-point cross test using Elo and En-1 as marker genes, the bilirubin UDPGT gene was mapped at position 37 on chromosome 1 [10].
 

Other interactions of Cryge

  • The mutant allele Crygbnop (formerly Cat2(nop)) is caused by a replacement of 11 bp by 4 bp in the third exon of Crygb, while a C-->G transversion in exon 3 of Cryge has been found for the Cryget (formerly Cat2(t)) mutation [11].
 

Analytical, diagnostic and therapeutic context of Cryge

References

  1. Endogenous retroviral insertion in Cryge in the mouse No3 cataract mutant. Nag, N., Peterson, K., Wyatt, K., Hess, S., Ray, S., Favor, J., Bogani, D., Lyon, M., Wistow, G. Genomics (2007) [Pubmed]
  2. A frameshift mutation in the gamma E-crystallin gene of the Elo mouse. Cartier, M., Breitman, M.L., Tsui, L.C. Nat. Genet. (1992) [Pubmed]
  3. Genetic and allelic heterogeneity of Cryg mutations in eight distinct forms of dominant cataract in the mouse. Graw, J., Neuhäuser-Klaus, A., Klopp, N., Selby, P.B., Löster, J., Favor, J. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  4. Ethylnitrosourea-induced mutation in mice leads to the expression of a novel protein in the eye and to dominant cataracts. Graw, J., Klopp, N., Löster, J., Soewarto, D., Fuchs, H., Becker-Follmann, J., Reis, A., Wolf, E., Balling, R., Habré de Angelis, M. Genetics (2001) [Pubmed]
  5. Ethylnitrosourea-induced base pair substitution affects splicing of the mouse gammaE-crystallin encoding gene leading to the expression of a hybrid protein and to a cataract. Graw, J., Neuhäuser-Klaus, A., Löster, J., Klopp, N., Favor, J. Genetics (2002) [Pubmed]
  6. Close linkage of the dominant cataract mutations (Cat-2) with Idh-1 and cryge on mouse chromosome 1. Löster, J., Pretsch, W., Sandulache, R., Schmitt-John, T., Lyon, M.F., Graw, J. Genomics (1994) [Pubmed]
  7. Mapping of six dominant cataract genes in the mouse. Everett, C.A., Glenister, P.H., Taylor, D.M., Lyon, M.F., Kratochvilova-Loester, J., Favor, J. Genomics (1994) [Pubmed]
  8. Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter. Lengler, J., Krausz, E., Tomarev, S., Prescott, A., Quinlan, R.A., Graw, J. Nucleic Acids Res. (2001) [Pubmed]
  9. Defect of a fiber cell-specific 94-kDa protein in the lens of inherited microphthalmic mutant mouse Elo. Masaki, S., Tamai, K., Shoji, R., Watanabe, T. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  10. Mapping of the mouse bilirubin UDP-glucuronosyltransferase gene (Gnt-1) to chromosome 1 by restriction fragment length variations. Sato, H., Sakai, Y., Koiwai, O., Watanabe, T. Biochem. Genet. (1992) [Pubmed]
  11. Three murine cataract mutants (Cat2) are defective in different gamma-crystallin genes. Klopp, N., Favor, J., Löster, J., Lutz, R.B., Neuhäuser-Klaus, A., Prescott, A., Pretsch, W., Quinlan, R.A., Sandilands, A., Vrensen, G.F., Graw, J. Genomics (1998) [Pubmed]
  12. Organ culture and immunohistochemistry of the genetically malformed lens, in eye lens obsolescence, Elo, of the mouse. Watanabe, K., Fujisawa, H., Oda, S., Kameyama, Y. Exp. Eye Res. (1980) [Pubmed]
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