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Gene Review

GALM  -  galactose mutarotase (aldose 1-epimerase)

Homo sapiens

Synonyms: Aldose 1-epimerase, BLOCK25, GLAT, Galactose mutarotase, HEL-S-63p, ...
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Disease relevance of GALM

  • Sequence analysis indicates that the yeast epimerase has an N-terminal domain (residues 1-377) that shows significant similarity with Escherichia coli and human UDPgalactose 4-epimerase, and a C-terminal domain (residues 378-699), which shows extensive identity to either the bacterial or human aldose 1-epimerase (mutarotase) [1].

High impact information on GALM


Chemical compound and disease context of GALM


Associations of GALM with chemical compounds


Other interactions of GALM

  • The risk of death was a factor of 6.1 higher if GALMP - GABPD of > or = 8 days was combined with increased (> 2 x multiple of median) maternal alpha-fetoprotein measured in the 2nd trimester [4].


  1. UDPgalactose 4-epimerase from Saccharomyces cerevisiae. A bifunctional enzyme with aldose 1-epimerase activity. Majumdar, S., Ghatak, J., Mukherji, S., Bhattacharjee, H., Bhaduri, A. Eur. J. Biochem. (2004) [Pubmed]
  2. Molecular structure of human galactose mutarotase. Thoden, J.B., Timson, D.J., Reece, R.J., Holden, H.M. J. Biol. Chem. (2004) [Pubmed]
  3. Identification and characterisation of human aldose 1-epimerase. Timson, D.J., Reece, R.J. FEBS Lett. (2003) [Pubmed]
  4. A discrepancy between gestational age estimated by last menstrual period and biparietal diameter may indicate an increased risk of fetal death and adverse pregnancy outcome. Nguyen, T., Larsen, T., Engholm, G., Møller, H. BJOG : an international journal of obstetrics and gynaecology. (2000) [Pubmed]
  5. New synchrotron radiation circular dichroism end-station on DISCO beamline at SOLEIL synchrotron for biomolecular analysis. Miron, S., Réfregiers, M., Gilles, A.M., Maurizot, J.C. Biochim. Biophys. Acta (2005) [Pubmed]
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