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Chemical Compound Review

Udpgal     [[(2R,3S,4R,5R)-5-(2,4- dioxopyrimidin-1...

Synonyms: Udp galactose, AC1OAGKN, CHEBI:18307, Uridinediphosphogalactose, Uridine diphosphogalactose, ...
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Disease relevance of Udpgal


High impact information on Udpgal


Chemical compound and disease context of Udpgal


Biological context of Udpgal


Anatomical context of Udpgal


Associations of Udpgal with other chemical compounds


Gene context of Udpgal

  • The modulation of UDPglucose and UDPgalactose concentrations, occurring after the presentation of galactose to cells, as a result of the combined actions of GALT and UDPgalactose-4-epimerase, may be important in determining rates of synthesis of complex glycoconjugates [21].
  • The distribution and partial characterization of UDPgalactose: N-acetylgalactosamine mucin galactosyltransferase activity from rat small intestine and its sensitivity to Zn2+ [22].
  • These results demonstrate that the S. cerevisiae UDPgalactose 4-epimerase is a bifunctional enzyme with aldose 1-epimerase activity [23].
  • Impairment of the human enzyme UDPgalactose 4-epimerase (hGALE) results in epimerase-deficiency galactosaemia, an inborn error of metabolism with variable biochemical presentation and clinical outcomes reported to range from benign to severe [24].
  • The levels of UDPglucose and UDPgalactose (UDPGal) have been measured in erythrocytes of seven patients with galactokinase deficiency [25].

Analytical, diagnostic and therapeutic context of Udpgal


  1. Two promoters, one inducible and one constitutive, control transcription of the Streptomyces lividans galactose operon. Fornwald, J.A., Schmidt, F.J., Adams, C.W., Rosenberg, M., Brawner, M.E. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  2. Sugar nucleotide concentrations in red blood cells of patients on protein- and lactose-limited diets: effect of galactose supplementation. Gibson, J.B., Berry, G.T., Palmieri, M.J., Reynolds, R.A., Mazur, A.T., Segal, S. Am. J. Clin. Nutr. (1996) [Pubmed]
  3. Reaction of uridine diphosphate galactose 4-epimerase with a suicide inactivator. Flentke, G.R., Frey, P.A. Biochemistry (1990) [Pubmed]
  4. Defective galactosylation in galactosemia: is low cell UDPgalactose an explanation? Segal, S. Eur. J. Pediatr. (1995) [Pubmed]
  5. UDPgalactose epimerase in lens and fibroblasts: activity expression in patients with cataracts and mental retardation. Shin, Y.S., Korenke, G.C., Huppke, P., Knerr, I., Podskarbi, T. J. Inherit. Metab. Dis. (2000) [Pubmed]
  6. Evidence for a novel enzymatic mechanism of neural crest cell migration on extracellular glycoconjugate matrices. Runyan, R.B., Maxwell, G.D., Shur, B.D. J. Cell Biol. (1986) [Pubmed]
  7. Perturbing cell surface beta-(1,4)-galactosyltransferase on F9 embryonal carcinoma cells arrests cell growth and induces laminin synthesis. Maillet, C.M., Shur, B.D. J. Cell. Sci. (1994) [Pubmed]
  8. Embryonal carcinoma cell adhesion: the role of surface galactosyltransferase and its 90K lactosaminoglycan substrate. Shur, B.D. Dev. Biol. (1983) [Pubmed]
  9. UDPgalactose inhibits blastocyst formation in the mouse. Implications for the mode of action of T/t-complex mutations. Shur, B.D., Oettgen, P., Bennett, D. Dev. Biol. (1979) [Pubmed]
  10. Uridine diphosphate hexoses in leukocytes and fibroblasts of classic galactosemics and patients with other metabolic diseases. Gibson, J.B., Reynolds, R.A., Palmieri, M.J., States, B., Berry, G.T., Segal, S. Pediatr. Res. (1994) [Pubmed]
  11. Comparison of erythrocyte uridine sugar nucleotide levels in normals, classic galactosemics, and patients with other metabolic disorders. Gibson, J.B., Reynolds, R.A., Palmieri, M.J., Berry, G.T., Elsas, L.J., Levy, H.L., Segal, S. Metab. Clin. Exp. (1995) [Pubmed]
  12. Galactosyltransferase activity and cell growth: uridine diphosphate (UDP)galactose inhibition of murine leukemic L1210 cells. Klohs, W.D., Wilson, J.R., Weiser, M.M., Frankfurt, O., Bernacki, R.J. J. Cell. Physiol. (1984) [Pubmed]
  13. Galactosyltransferase defects in reeler mouse brains. Shur, B.D. J. Neurochem. (1982) [Pubmed]
  14. Cloning of a putative monogalactosyldiacylglycerol synthase gene from rice (Oryza sativa L.) plants and its expression in response to submergence and other stresses. Qi, Y., Yamauchi, Y., Ling, J., Kawano, N., Li, D., Tanaka, K. Planta (2004) [Pubmed]
  15. Synthesis of non-hydroxy-galactosylceramides and galactosyldiglycerides by hydroxy-ceramide galactosyltransferase. van der Bijl, P., Strous, G.J., Lopes-Cardozo, M., Thomas-Oates, J., van Meer, G. Biochem. J. (1996) [Pubmed]
  16. 31P NMR spectra of intact red blood cells: quantitation of UDPGlucose and UDPGalactose. Wehrli, S.L., Palmieri, M.J., Reynolds, R.A., Segal, S. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (1993) [Pubmed]
  17. Effect of estradiol and progesterone on UDPgalactose pyrophosphatase activity in the endometrium of ovariectomized rats. Jato-Rodriguez, J.J., Nelson, J.D., Mookerjea, S. Biochim. Biophys. Acta (1976) [Pubmed]
  18. Enhancement of UDPgalactose: glycoprotein galactosyltransferase in cultured human skin fibroblasts by cationic polypeptides. Rao, G.J., Chyatte, D., Nadler, H.L. Biochim. Biophys. Acta (1978) [Pubmed]
  19. Distribution, purification and characterization of rat intestinal UDPgalactose: N-acetylglucosaminyl(beta 1----4)galactosyltransferase. Weiser, M.M., Majumdar, S., Wilson, J.R., Luther, R. Biochim. Biophys. Acta (1987) [Pubmed]
  20. Impaired ganglioside synthesis in rat liver after D-galactosamine administration in vivo. Rupprecht, E., Hans, C., Leonard, G., Decker, K. Biochim. Biophys. Acta (1976) [Pubmed]
  21. Effect of glucose and galactose loading in normal subjects on red and white blood cell uridine diphosphate sugars. Gibson, J.B., Berry, G.T., Mazur, A.T., Palmieri, M.J., Reynolds, R.A., Segal, S. Biochem. Mol. Med. (1995) [Pubmed]
  22. The distribution and partial characterization of UDPgalactose: N-acetylgalactosamine mucin galactosyltransferase activity from rat small intestine and its sensitivity to Zn2+. Wilson, J.R., Deinhart, J.A., Weiser, M.M. Biochim. Biophys. Acta (1987) [Pubmed]
  23. UDPgalactose 4-epimerase from Saccharomyces cerevisiae. A bifunctional enzyme with aldose 1-epimerase activity. Majumdar, S., Ghatak, J., Mukherji, S., Bhattacharjee, H., Bhaduri, A. Eur. J. Biochem. (2004) [Pubmed]
  24. Studies of the V94M-substituted human UDPgalactose-4-epimerase enzyme associated with generalized epimerase-deficiency galactosaemia. Wohlers, T.M., Fridovich-Keil, J.L. J. Inherit. Metab. Dis. (2000) [Pubmed]
  25. Uridine nucleotide sugars in erythrocytes of patients with galactokinase deficiency. Xu, Y.K., Ng, W.G., Kaufman, F.R., Donnell, G.N. J. Inherit. Metab. Dis. (1989) [Pubmed]
  26. The concentration of red blood cell UDPglucose and UDPgalactose determined by high-performance liquid chromatography. Palmieri, M.J., Berry, G.T., Player, D.A., Rogers, S., Segal, S. Anal. Biochem. (1991) [Pubmed]
  27. 31P NMR analysis of red blood cell UDPGlucose and UDPGalactose: comparison with HPLC and enzymatic methods. Wehrli, S.L., Palmieri, M.J., Berry, G.T., Kirkman, H.N., Segal, S. Anal. Biochem. (1992) [Pubmed]
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