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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

COL15A1  -  collagen, type XV, alpha 1

Homo sapiens

Synonyms: Collagen alpha-1(XV) chain
 
 
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High impact information on COL15A1

  • Complete exon-intron organization of the human gene for the alpha1 chain of type XV collagen (COL15A1) and comparison with the homologous COL18A1 gene [1].
  • The human gene for the alpha1 chain of type XV collagen (COL15A1) is about 145 kilobases in size and contains 42 exons [1].
  • The results obtained using the hybrid cell lines showed that this newly identified collagen gene, COL15A1, is present in the pter --> q34 region of chromosome 9 [2].
  • TGF-beta enhanced the expression of the type XV collagen gene (COL15A1) in a time-dependent manner, up to 4.3-fold after 24 h of incubation, whereas TNF-alpha and IL-1beta reduced the mRNA steady-state levels by 32 and 80%, respectively [3].
  • Interphase FISH showed that COL15A1 lies distal to the region bounded by D9S180 and D9S196 and that ZNF169 is adjacent to D9S196 [4].
 

Other interactions of COL15A1

  • Mutation analysis excluded COL15A1, a member of the multiplexin collagen subfamily similar to COL18A1, as being responsible for KNO2 [5].

References

  1. Complete exon-intron organization of the human gene for the alpha1 chain of type XV collagen (COL15A1) and comparison with the homologous COL18A1 gene. Hägg, P.M., Muona, A., Liétard, J., Kivirikko, S., Pihlajaniemi, T. J. Biol. Chem. (1998) [Pubmed]
  2. Chromosomal assignment of a gene encoding a new collagen type (COL15A1) to 9q21 --> q22. Huebner, K., Cannizzaro, L.A., Jabs, E.W., Kivirikko, S., Manzone, H., Pihlajaniemi, T., Myers, J.C. Genomics (1992) [Pubmed]
  3. Cytokine modulation of type XV collagen gene expression in human dermal fibroblast cultures. Kivirikko, S., Mauviel, A., Pihlajaniemi, T., Uitto, J. Exp. Dermatol. (1999) [Pubmed]
  4. Pulsed-field gel electrophoresis and FISH mapping of chromosome 9q22: placement of a novel zinc finger gene within the NBCCS and ESS1 region. Levanat, S., Chidambaram, A., Wicking, C., Bray-Ward, P., Pressman, C., Toftgard, R., Gailani, M.R., Myers, J.C., Wainwright, B., Dean, M., Bale, A.E. Cytogenet. Cell Genet. (1997) [Pubmed]
  5. Knobloch syndrome: novel mutations in COL18A1, evidence for genetic heterogeneity, and a functionally impaired polymorphism in endostatin. Menzel, O., Bekkeheien, R.C., Reymond, A., Fukai, N., Boye, E., Kosztolanyi, G., Aftimos, S., Deutsch, S., Scott, H.S., Olsen, B.R., Antonarakis, S.E., Guipponi, M. Hum. Mutat. (2004) [Pubmed]
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