Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Cyp2f2 - cytochrome P450, family 2, subfamily f,...

Mus musculus

Synonyms: CYPIIF2, Cyp2f, Cyp2f-2, Cytochrome P450 2F2, Cytochrome P450-NAH-2, ...

Buckpitt, A. et al., O'Reilly, M.A. et al., Ritter, J.K. et al., Mango, G.W. et al., Ye, X. et al.

O'Reilly, Staversky, Stripp, Finkelstein,

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High impact information on Cyp2f2

These studies support the view that the rate and stereoselectivity of naphthalene metabolism to naphthalene 1R,2S-oxide catalyzed by cytochrome P450 2F2 are critical determinants in the species-specific and region-selective cytotoxicity of naphthalene in mice [1].
Expression of SP-B mRNA modestly increased and Clara cell secretory protein and cytochrome P-450 2F2 mRNAs decreased, providing additional evidence that hyperoxia injured pulmonary epithelial cells [2].
We have isolated a cDNA clone, Nah-2, encoding the cytochrome P-450Nah (naphthalene hydroxylase) from a mouse lung lambda ZAP cDNA library using anti-cytochrome P-450Nah IgG as a probe [3].
Using northern analysis, RNase protection assay, and RT-PCR, we show that the Cyp2f2 mRNA levels are decreased in mouse liver following DEHP treatment [4].
Increases in IL-6 and MT mRNA abundance were detected by 2 h of exposure to 1 part/million ozone and preceded reductions in Clara cell CYP2F2 mRNA expression [5].

References

Relationship of cytochrome P450 activity to Clara cell cytotoxicity. IV. Metabolism of naphthalene and naphthalene oxide in microdissected airways from mice, rats, and hamsters. Buckpitt, A., Chang, A.M., Weir, A., Van Winkle, L., Duan, X., Philpot, R., Plopper, C. Mol. Pharmacol. (1995) [Pubmed]
Exposure to hyperoxia induces p53 expression in mouse lung epithelium. O'Reilly, M.A., Staversky, R.J., Stripp, B.R., Finkelstein, J.N. Am. J. Respir. Cell Mol. Biol. (1998) [Pubmed]
Mouse pulmonary cytochrome P-450 naphthalene hydroxylase: cDNA cloning, sequence, and expression in Saccharomyces cerevisiae. Ritter, J.K., Owens, I.S., Negishi, M., Nagata, K., Sheen, Y.Y., Gillette, J.R., Sasame, H.A. Biochemistry (1991) [Pubmed]
Suppression of cytochrome P450 Cyp2f2 mRNA levels in mice by the peroxisome proliferator diethylhexylphthalate. Ye, X., Lu, L., Gill, S.S. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
Clara cell secretory protein deficiency increases oxidant stress response in conducting airways. Mango, G.W., Johnston, C.J., Reynolds, S.D., Finkelstein, J.N., Plopper, C.G., Stripp, B.R. Am. J. Physiol. (1998) [Pubmed]

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LOC612477	Canis lupus familiaris
CYP2F1	Homo sapiens
CYP2F1	Macaca mulatta
LOC738883	Pan troglodytes
Cyp2f4	Rattus norvegicus

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