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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Dapk3  -  death-associated protein kinase 3

Mus musculus

Synonyms: DAP kinase 3, DAP-like kinase, Death-associated protein kinase 3, Dlk, MYPT1 kinase, ...
 
 
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High impact information on Dapk3

  • We have identified a novel serine/threonine kinase, designated ZIP kinase, which mediates apoptosis [1].
  • Overexpression of intact ZIP kinase but not catalytically inactive kinase mutants led to the morphological changes of apoptosis in NIH 3T3 cells, suggesting that the cell death-inducing activity of ZIP kinase depends on its intrinsic kinase activity [1].
  • Binding of Par-4 to the actin cytoskeleton is essential for Par-4/Dlk-mediated apoptosis [2].
  • Quantitative analysis revealed that the status of p53 had no major influence on cellular susceptibility to Dlk/ZIP kinase-triggered cell death [3].
 

Biological context of Dapk3

  • Cell death mediated by Par-4 and its interaction partner DAP like kinase (Dlk) is characterized by dramatic changes of the cytoskeleton [2].
 

Anatomical context of Dapk3

  • To uncover the role of the cytoskeleton in Par-4/Dlk-mediated apoptosis, we analyzed Par-4 for a direct association with cytoskeletal structures [2].
 

Associations of Dapk3 with chemical compounds

References

  1. ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. Kawai, T., Matsumoto, M., Takeda, K., Sanjo, H., Akira, S. Mol. Cell. Biol. (1998) [Pubmed]
  2. Binding of Par-4 to the actin cytoskeleton is essential for Par-4/Dlk-mediated apoptosis. Vetterkind, S., Illenberger, S., Kubicek, J., Boosen, M., Appel, S., Naim, H.Y., Scheidtmann, K.H., Preuss, U. Exp. Cell Res. (2005) [Pubmed]
  3. The death associated protein (DAP) kinase homologue Dlk/ZIP kinase induces p19ARF- and p53-independent apoptosis. Kögel, D., Reimertz, C., Düssmann, H., Mech, P., Scheidtmann, K.H., Prehn, J.H. Eur. J. Cancer (2003) [Pubmed]
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