Disease relevance of Pedigree

• Surgery was performed in 35 patients with familial adenomatous polyposis (FAP) from 22 family trees [1].
• Direct virus identification by polymerase chain reaction in lung tissue of serologically positive rodents was performed to verify antibody results and to determine the genetic identity of viral RNA by phylogenetic analysis of a part of the hantavirus M segment [2].

High impact information on Pedigree

• Analysis of the genealogic tree of the complete family groups showed that the apoprotein (apo) AIMilano is transmitted as an autosomal dominant trait, all carriers coming from a single mating couple, living in the eighteenth century [3].
• The sequence on an integrative plasmid was also shown to recombine with the INO1 locus, thereby confirming its genetic identity [4].
• Genetic identity of Fukuyama-type congenital muscular dystrophy and Walker-Warburg syndrome [5].
• Phylogenetic analysis shows that the two chick enzymes form a separate branch in the CYP1A family tree distinct from mammalian CYP1A1 and -1A2 and from fish CYP1A enzymes [6].
• The completion of the human tyrosine kinase family tree provides a framework for further advances in biomedical science [7].

Biological context of Pedigree

• Southern blot analysis with a probe from a separate region of the P. aeruginosa chromosome, a 741-base-pair PstI-NruI DNA fragment adjacent to the exotoxin A gene, also revealed genetic identity among these five clinical isolates [8].
• In this family, all affected members harbour the same APC germline mutation (5945delA), but display marked phenotypic variability, in particular regarding the occurrence of extracolonic disease that segregates in several branches of the family tree [9].
• To resolve the genetic identity of NFAR-1 and -2, we carried out sequence analysis of genomic and cDNA NFAR clones and determined that the coding region of this gene spans 16.2 kb and comprises 21 exons [10].
• Haplotype XV (A3, Cl, D2, Fl, Il) is the main Y-chromosome haplotype in West Europe, with a Basque focus in Southwestern Europe. This study demonstrates that the geographic distribution of Y-chromosome variation for p49a,f TaqI haplotype XV reveals an important genetic identity for populations that live in the Occidental part of Europe [11].
• Clinical and genetic studies including exploration of his family tree proved that he and his maternal relatives had the disease with the missense mutation, Arg528His (CGC --> CAC) [12].

Anatomical context of Pedigree

• Biochemical and genetic identity of alpha-keto acid reductase and cytoplasmic malate dehydrogenase from human erythrocytes [13].

Associations of Pedigree with chemical compounds

• The association between parental history of alcoholism and the nature of alcoholism was assessed using a more reliable measure of family history (Family Tree Questionnaire) and a more comprehensive inventory of alcoholism (Alcohol Use Inventory) than used in earlier studies [14].
• Juglone, a toxic compound found in all parts of plants of the walnut tree family Jugans, was evaluated as the possible toxin involved in black walnut shaving-associated laminitis in the horse [15].
• The results establish the genetic identity of LI virus on the Lochindorb Estate. There was a high correlation between the results obtained by RT-PCR and infectivity assays [16].
• In Japan 1052 FAP patients in 688 family trees have been registered at the National Polyposis Center. In Hamamatsu University School of Medicine, we have been treating 50 patients in 28 family trees [17].
• MUC5AC is thus the first large, subunit-based, gel-forming respiratory mucin identified and this glycoprotein is biochemically distinct from at least one other population of large, gel-forming mucins also composed of subunits but lacking a genetic identity [18].

Gene context of Pedigree

• However, three silent polymorphisms in the DNA coding region indicate that Scn1b is close to qv, and is within a region of genetic identity with DBA/2J, the inbred background on which the qvJ allele arose [19].
• The two new branches that have been added to the CYP1 family tree significantly add to our understanding of P450 evolution [20].
• The genetic identities of the major mucin (populations I and II) and a minor component (population IV) were not established [21].
• The two P. aeruginosa strains used in these studies, 388 and 388delta exoS, maintained genetic identity, with the exception that strain 388delta exoS lacked production of the 49-kDa form of ExoS [22].
• Genetic identity and differential expression of p38.5 (Haymaker) in human malignant and nonmalignant cells [23].

References