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Gene Review

GPR151  -  G protein-coupled receptor 151

Homo sapiens

Synonyms: G-protein coupled receptor PGR7, GALR4, GALRL, GPCR, GPCR-2037, ...
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Disease relevance of GPR151


High impact information on GPR151

  • Among these GPCR targets are the receptors for peptides like bradykinin, chemokines, complement anaphylatoxins, corticotropin releasing factor, endothelins, melanocortins, tachykinins, urocortins, as well as the protease activated receptors (PARs) [2].
  • The coding regions of this family of receptors share 97-99% sequence similarity at both the protein and nucleotide level, and they also share high sequence identity with vertebrate galanin and orphanin-FQ/nociceptin GPCR families [3].
  • We conclude that galnon has multiple sites of interaction within the GPCR signaling cascade which mediate its physiological effects [4].

Analytical, diagnostic and therapeutic context of GPR151

  • A PCR search of rat brain cDNA retrieved a clone partially encoding a GPCR [5].


  1. Regulation of limbic status epilepticus by hippocampal galanin type 1 and type 2 receptors. Mazarati, A., Lu, X. Neuropeptides (2005) [Pubmed]
  2. Nonpeptide ligands that target peptide-activated GPCRs in inflammation. Blakeney, J.S., Fairlie, D.P. Current medicinal chemistry. (2005) [Pubmed]
  3. Multimeric CREB-binding sites in the promoter regions of a family of G-protein-coupled receptors related to the vertebrate galanin and nociceptin/orphanin-FQ receptor families. Saunders, S.E., Burke, J.F., Benjamin, P.R. Eur. J. Neurosci. (2000) [Pubmed]
  4. Multiple interaction sites of galnon trigger its biological effects. Florén, A., Sollenberg, U., Lundström, L., Zorko, M., Stojan, J., Budihna, M., Wheatley, M., Martin, N.P., Kilk, K., Mazarati, A., Bartfai, T., Lindgren, M., Langel, U. Neuropeptides (2005) [Pubmed]
  5. Discovery of a receptor related to the galanin receptors. Lee, D.K., Nguyen, T., O'Neill, G.P., Cheng, R., Liu, Y., Howard, A.D., Coulombe, N., Tan, C.P., Tang-Nguyen, A.T., George, S.R., O'Dowd, B.F. FEBS Lett. (1999) [Pubmed]
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