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Gene Review:

Klk1b22 - kallikrein 1-related peptidase b22

Mus musculus

Synonyms: Beta-NGF-endopeptidase, EGF-BP A, Egfbp-1, Egfbp1, Epidermal growth factor-binding protein type A, ...

Fahnestock, M. et al., Cleutjens, K.B. et al., Kikkawa, Y. et al.

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High impact information on Klk1b22

Therefore, the 6-kb PSA-LacZ transgene followed the expression pattern of the PSA gene in humans, which is almost completely prostate-specific, rather than that of mGK22 in mice [1].
beta-NGF-endopeptidase: structure and activity of a kallikrein encoded by the gene mGK-22 [2].
The first 30 NH2-terminal amino acids of beta-NGF-endopeptidase were sequenced [2].
These studies further supported the view that beta-NGF-endopeptidase acts on both NGF and kininogen [2].
With the same substrate, mK22 (beta-NGF endopeptidase) gave two products, renin and arginyl-renin; whereas mK1 (true tissue kallikrein) did not process it at all [3].

Analytical, diagnostic and therapeutic context of Klk1b22

Purified beta-NGF-endopeptidase migrated as a single band on isoelectric focusing and reducing SDS-polyacrylamide gels [2].

References

A 6-kb promoter fragment mimics in transgenic mice the prostate-specific and androgen-regulated expression of the endogenous prostate-specific antigen gene in humans. Cleutjens, K.B., van der Korput, H.A., Ehren-van Eekelen, C.C., Sikes, R.A., Fasciana, C., Chung, L.W., Trapman, J. Mol. Endocrinol. (1997) [Pubmed]
beta-NGF-endopeptidase: structure and activity of a kallikrein encoded by the gene mGK-22. Fahnestock, M., Woo, J.E., Lopez, G.A., Snow, J., Walz, D.A., Arici, M.J., Mobley, W.C. Biochemistry (1991) [Pubmed]
Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22). Kikkawa, Y., Yamanaka, N., Tada, J., Kanamori, N., Tsumura, K., Hosoi, K. Biochim. Biophys. Acta (1998) [Pubmed]

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KLK3	Homo sapiens
KLK3	Macaca mulatta
Klk1b4	Mus musculus
Klk1b8	Mus musculus
Klk1b16	Mus musculus
Klk1	Mus musculus
Klk1b5	Mus musculus
Klk1b1	Mus musculus
Klk1b9	Mus musculus
Klk1b3	Mus musculus
Klk1b11	Mus musculus
Klk1b24	Mus musculus
Klk1b27	Mus musculus
Klk1b26	Mus musculus
Klk1b21	Mus musculus

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