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Gene Review

Kng1  -  kininogen 1

Mus musculus

Synonyms: H-kininigen, Kininogen-1, Kng, L-kininogen
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Disease relevance of Kng1


High impact information on Kng1

  • The protein of 448 amino acids contains a glycine/alanine-rich amino terminal region, a histidine-rich sequence with homology to a region of kininogen associated with clotting, a POU domain and a short proline/histidine-rich carboxy terminal region [6].
  • By contrast, in kininogen-deficient Brown Norway Katholiek rats (BN-Ka rats), which cannot generate intrinsic bradykinin (BK), the weights of the tumors and the extent of angiogenesis were significantly less than those in BN-Ki rats [7].
  • The inhibitor also liberated kinin upon treatment with trypsin or mouse glandular kallikrein, indicating that the inhibitor is a kininogen, and the kinin liberated upon trypsinization was identified as bradykinin [8].
  • Hydroxyproline, which was recently identified in the bradykinin sequence of kininogen from the ascitic fluid of a cancer patient, was not found in the kinin moiety of this mouse kininogen [9].
  • Low molecular weight kininogen was purified from mouse plasma and used as substrate for the three enzymes, and the kinin released by the enzymes was assayed by its ability to induce contraction of isolated rat uterus [10].

Biological context of Kng1


Anatomical context of Kng1


Associations of Kng1 with chemical compounds


Physical interactions of Kng1


Enzymatic interactions of Kng1


Other interactions of Kng1


Analytical, diagnostic and therapeutic context of Kng1

  • Northern blotting or reverse transcription-polymerase chain reaction followed by Southern blotting using mouse L- and H-kininogen cDNAs demonstrated that both L- and H-kininogens are predominantly expressed in the liver and kidney [11].
  • We isolated PCR, RNA ligase-mediated rapid amplification of cDNA ends (RLM-RACE-PCR)-, and RT-PCR-generated clones from mouse kininogen family transcripts [25].
  • The specificity of the monoclonal antibodies was confirmed by the immunoprecipitation of kininogen with the antibodies coupled to Sepharose-4B followed by SDS-polyacrylamide gel electrophoresis [18].
  • Western blots using a bradykinin-directed monoclonal, as well as a polyclonal anti-mouse low-molecular-weight kininogen antibody, showed that ir-kininogen had a molecular weight of 80,000 and that it contained a kinin moiety [16].
  • In contrast, levels of both low-molecular-weight kininogen and tissue kallikrein mRNAs were increased 7, 14 and 28 d after aortic constriction [3].


  1. Regulation of angiogenesis by the kallikrein-kinin system. Colman, R.W. Curr. Pharm. Des. (2006) [Pubmed]
  2. Role of kinins in the cardioprotective effect of preconditioning: study of myocardial ischemia/reperfusion injury in B2 kinin receptor knockout mice and kininogen-deficient rats. Yang, X.P., Liu, Y.H., Scicli, G.M., Webb, C.R., Carretero, O.A. Hypertension (1997) [Pubmed]
  3. Expressions of bradykinin B2-receptor, kallikrein and kininogen mRNAs in the heart are altered in pressure-overload cardiac hypertrophy in mice. Yayama, K., Hiyoshi, H., Okamoto, H. Biol. Pharm. Bull. (2001) [Pubmed]
  4. Isolation and partial characterization of kinin-like peptides formed by acid protease from murine fibroblast L-929. Li, H.C., Back, N. Prep. Biochem. (1979) [Pubmed]
  5. Single-step purification of "kallikrein-resistant" kininogen from rat plasma using monoclonal-antibody immunoaffinity chromatography. Bedi, G.S., Back, N. Prep. Biochem. (1985) [Pubmed]
  6. Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain. Suzuki, N., Rohdewohld, H., Neuman, T., Gruss, P., Schöler, H.R. EMBO J. (1990) [Pubmed]
  7. Host stromal bradykinin B2 receptor signaling facilitates tumor-associated angiogenesis and tumor growth. Ikeda, Y., Hayashi, I., Kamoshita, E., Yamazaki, A., Endo, H., Ishihara, K., Yamashina, S., Tsutsumi, Y., Matsubara, H., Majima, M. Cancer Res. (2004) [Pubmed]
  8. Thiol proteinase inhibitor in the ascitic fluid of sarcoma 180 tumor-bearing mice. Itoh, N., Yokota, S., Takagishi, U., Hatta, A., Okamoto, H. Cancer Res. (1987) [Pubmed]
  9. Cysteine proteinase inhibitor in the ascitic fluid of sarcoma 180 tumor-bearing mice is a low molecular weight kininogen. Partial NH2- and COOH-terminal sequences and susceptibility to various glandular kallikreins. Sueyoshi, T., Uwani, M., Itoh, N., Okamoto, H., Muta, T., Tokunaga, F., Takada, K., Iwanaga, S. J. Biol. Chem. (1990) [Pubmed]
  10. The relationship between glandular kallikrein and growth factor-processing proteases of mouse submaxillary gland. Bothwell, M.A., Wilson, W.H., Shooter, E.M. J. Biol. Chem. (1979) [Pubmed]
  11. Molecular cloning of cDNAs for mouse low-molecular-weight and high-molecular-weight prekininogens. Takano, M., Kondo, J., Yayama, K., Otani, M., Sano, K., Okamoto, H. Biochim. Biophys. Acta (1997) [Pubmed]
  12. Bovine milk kininogen fragment 1.2 promotes the proliferation of osteoblastic MC3T3-E1 cells. Yamamura, J., Takada, Y., Goto, M., Kumegawa, M., Aoe, S. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  13. The agonist selectivity of a mouse B1 bradykinin receptor differs from human and rabbit B1 receptors. Hess, J.F., Derrick, A.W., MacNeil, T., Borkowski, J.A. Immunopharmacology (1996) [Pubmed]
  14. Structure and other chemical characterizations of gila toxin, a lethal toxin from lizard venom. Datta, G., Tu, A.T. J. Pept. Res. (1997) [Pubmed]
  15. Immunohistochemical distributions of the tissue kallikrein-kinin system in ischemic and non-ischemic mouse heart. Yano, Y., Ozono, R., Nakashima, H., Oishi, Y., Kambe, M., Hosoi, K., Oshima, T. J. Cardiovasc. Pharmacol. (2003) [Pubmed]
  16. Murine fibroblasts synthesize and secrete kininogen in response to cyclic-AMP, prostaglandin E2 and tumor necrosis factor. Takano, M., Yokoyama, K., Yayama, K., Okamoto, H. Biochim. Biophys. Acta (1995) [Pubmed]
  17. Expression of low-molecular-weight kininogen in mouse vascular smooth muscle cells. Yayama, K., Shibata, H., Takano, M., Okamoto, H. Biol. Pharm. Bull. (1998) [Pubmed]
  18. Monoclonal antibodies to rat plasma kininogen. Bedi, G.S., Back, N. Adv. Exp. Med. Biol. (1986) [Pubmed]
  19. Plasma levels of bradykinin are suppressed in factor XII-deficient mice. Iwaki, T., Castellino, F.J. Thromb. Haemost. (2006) [Pubmed]
  20. Atlantic salmon (Salmo salar L.) skin contains a novel kininogen and another cysteine proteinase inhibitor. Ylönen, A., Rinne, A., Herttuainen, J., Bogwald, J., Järvinen, M., Kalkkinen, N. Eur. J. Biochem. (1999) [Pubmed]
  21. Characterization of cysteine proteases functioning in degradation of dynorphin in neuroblastoma cells: evidence for the presence of a novel enzyme with strict specificity toward paired basic residues. Satoh, M., Yokosawa, H., Ishii, S. J. Neurochem. (1989) [Pubmed]
  22. Reduction of sodium deoxycholic acid-induced scratching behaviour by bradykinin B2 receptor antagonists. Hayashi, I., Majima, M. Br. J. Pharmacol. (1999) [Pubmed]
  23. beta-NGF-endopeptidase: structure and activity of a kallikrein encoded by the gene mGK-22. Fahnestock, M., Woo, J.E., Lopez, G.A., Snow, J., Walz, D.A., Arici, M.J., Mobley, W.C. Biochemistry (1991) [Pubmed]
  24. Postischemic brain injury is exacerbated in mice lacking the kinin B2 receptor. Xia, C.F., Smith, R.S., Shen, B., Yang, Z.R., Borlongan, C.V., Chao, L., Chao, J. Hypertension (2006) [Pubmed]
  25. A second expressed kininogen gene in mice. Shesely, E.G., Hu, C.B., Alhenc-Gelas, F., Meneton, P., Carretero, O.A. Physiol. Genomics (2006) [Pubmed]
  26. A membrane-associated cysteine protease inhibitor from murine hepatoma. Moin, K., Emmert, L.T., Sloane, B.F. FEBS Lett. (1992) [Pubmed]
  27. Structural and immunological relationship between laminin and the cysteine proteinase inhibitor stefin. Keil-Dlouha, V., Paulsson, M., Joukoff, E., Lenarcic, B., Turk, V. Protein Seq. Data Anal. (1988) [Pubmed]
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