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Gene Review

Klk1b4  -  kallikrein 1-related pepidase b4

Mus musculus

Synonyms: 7S nerve growth factor alpha chain, Alpha-NGF, Kallikrein 1-related peptidase-like b4, Klk-4, Klk4, ...
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High impact information on Klk1b4


Biological context of Klk1b4

  • These findings suggest that the alpha-NGF backbone can be corrected to a functional enzyme by the addition of a normal N-terminal structure and two catalytic site substitutions and that the 7S complex requires one kallikrein subunit in the zymogen form and one in an active conformation [4].

Anatomical context of Klk1b4


Other interactions of Klk1b4

  • The two zinc ions that stabilize the complex are located at the relatively small interfaces between the alpha-NGF and gamma-NGF subunits [6].

Analytical, diagnostic and therapeutic context of Klk1b4

  • Antibodies have been prepared against alpha-NGF and purified by affinity chromatography so that they do not cross-react with gamma-NGF [3].
  • Site-directed mutagenesis of alpha-NGF to alter the N-terminus and three residues in loop 7, a region that contributes to the catalytic center, restored substantial catalytic activity against N-benzoyl arginine-p-nitroanilide as substrate in two derivatives although they were not as active as recombinant gamma-NGF [4].


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