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Gene Review

GPR119  -  G protein-coupled receptor 119

Homo sapiens

Synonyms: G-protein coupled receptor 119, GPCR2, Glucose-dependent insulinotropic receptor, hGPCR2
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Disease relevance of GPR119

  • GPR119 therefore represents a novel and attractive potential target for the therapy of obesity and related metabolic disorders [1].
  • Furthermore, we have used the recombinant receptor to discover novel selective small-molecule GPR119 agonists, typified by PSN632408, which suppress food intake in rats and reduce body weight gain and white adipose tissue deposition upon subchronic oral administration to high-fat-fed rats [1].


  1. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Overton, H.A., Babbs, A.J., Doel, S.M., Fyfe, M.C., Gardner, L.S., Griffin, G., Jackson, H.C., Procter, M.J., Rasamison, C.M., Tang-Christensen, M., Widdowson, P.S., Williams, G.M., Reynet, C. Cell metabolism. (2006) [Pubmed]
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