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Gene Review

Nek8  -  NIMA (never in mitosis gene a)-related...

Mus musculus

Synonyms: 4632401F23Rik, Jck, Never in mitosis A-related kinase 8, NimA-related protein kinase 8, Serine/threonine-protein kinase Nek8, ...
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Disease relevance of Nek8


High impact information on Nek8

  • In vitro expression of mutated Nek8 results in enlarged, multinucleated cells with an abnormal actin cytoskeleton [4].
  • The effect of jck mutation on the expression of Nek8, a NIMA-related (never in mitosis A) kinase, and polycystins in jck cilia is shown for the first time [5].
  • Four newly identified proteins were found to accumulate in the kidneys of jck mice with polycystic kidney disease (PKD) compared with their wild-type littermates [3].

Analytical, diagnostic and therapeutic context of Nek8


  1. A NIMA-related kinase, Fa2p, localizes to a novel site in the proximal cilia of Chlamydomonas and mouse kidney cells. Mahjoub, M.R., Qasim Rasi, M., Quarmby, L.M. Mol. Biol. Cell (2004) [Pubmed]
  2. NIMA-related kinases defective in murine models of polycystic kidney diseases localize to primary cilia and centrosomes. Mahjoub, M.R., Trapp, M.L., Quarmby, L.M. J. Am. Soc. Nephrol. (2005) [Pubmed]
  3. Nek8 mutation causes overexpression of galectin-1, sorcin, and vimentin and accumulation of the major urinary protein in renal cysts of jck mice. Valkova, N., Yunis, R., Mak, S.K., Kang, K., Kültz, D. Mol. Cell Proteomics (2005) [Pubmed]
  4. A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish. Liu, S., Lu, W., Obara, T., Kuida, S., Lehoczky, J., Dewar, K., Drummond, I.A., Beier, D.R. Development (2002) [Pubmed]
  5. Development of polycystic kidney disease in juvenile cystic kidney mice: insights into pathogenesis, ciliary abnormalities, and common features with human disease. Smith, L.A., Bukanov, N.O., Husson, H., Russo, R.J., Barry, T.C., Taylor, A.L., Beier, D.R., Ibraghimov-Beskrovnaya, O. J. Am. Soc. Nephrol. (2006) [Pubmed]
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