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Gene Review:

OR51E1 - olfactory receptor, family 51, subfamily E...

Homo sapiens

Synonyms: D-GPCR, DGPCR, G-protein coupled receptor 164, GPR136, GPR164, ...

Weigle, B. et al., Fuessel, S. et al.

Fuessel, Weigle, Schmidt, Baretton, Koch, Bachmann, Rieber, Wirth, Meye, Weigle, Fuessel, Ebner, Temme, Schmitz, Schwind, Kiessling, Rieger, Meye, Bachmann, Wirth, Rieber,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of OR51E1

When comparing the mean transcript level of 15 prostate cancer tissues to their non-tumorous counterparts, D-GPCR was almost 6-fold upregulated [1].

High impact information on OR51E1

Coupled in vitro transcription and translation of D-GPCR cDNA produced a protein band of approximately 28 kDa [1].
D-GPCR: a novel putative G protein-coupled receptor overexpressed in prostate cancer and prostate [1].
Quantification of D-GPCR transcripts in different human tissues by real-time PCR demonstrated 27-fold overexpression in prostate compared to skeletal muscle, the organ with second highest transcript numbers in males [1].
Quantification of D-GPCR transcripts in paired malignant and non-malignant prostate tissues of 106 patients with primary PCa by real-time PCR demonstrated a significant up-regulation of this gene in tumor samples [2].
The evaluation of D-GPCR expression as a potential molecular tumor marker was performed by receiver-operating characteristic curve (ROC) analysis resulting in an area under the curve (AUC) value of 0.6452 [2].

Analytical, diagnostic and therapeutic context of OR51E1

These data provide the basis for future studies evaluating the diagnostic potential of D-GPCR and its utility as a novel target in immunotherapy of prostate cancer [1].

References

D-GPCR: a novel putative G protein-coupled receptor overexpressed in prostate cancer and prostate. Weigle, B., Fuessel, S., Ebner, R., Temme, A., Schmitz, M., Schwind, S., Kiessling, A., Rieger, M.A., Meye, A., Bachmann, M., Wirth, M.P., Rieber, E.P. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
Transcript quantification of Dresden G protein-coupled receptor (D-GPCR) in primary prostate cancer tissue pairs. Fuessel, S., Weigle, B., Schmidt, U., Baretton, G., Koch, R., Bachmann, M., Rieber, E.P., Wirth, M.P., Meye, A. Cancer Lett. (2006) [Pubmed]

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OR51E1	Bos taurus
LOC485235	Canis lupus familiaris
OR51E1	Macaca mulatta
Olfr558	Mus musculus
LOC466342	Pan troglodytes
Olr63	Rattus norvegicus

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