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Gene Review

aac(3)-Ia  -  Aac(3)-Ia

Escherichia coli

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High impact information on aac(3)-Ia

  • Thirteen strains had integrons with a single cassette: aac(3)-Ia (9 strains), ant(2")-Ia (2 strains), or aac(6')-Ib (2 strains); 1 had aac(6')-Ib and oxa20 cassettes and an unknown gene; and 1 had an integron containing ant(2")-Ia and an oxa3 cassette truncated by IS6100 [1].
  • We have designated the genes from the R plasmids and this work aac(3)-Ia and aac(3)-Ib, respectively [2].
  • Intragenic probes specific for either aac(3)-Ia or aac(3)-Ib were used in hybridization studies with a series of gentamicin-, astromicin-, and sisomicin-resistant clinical isolates [2].


  1. Molecular characterization of integrons in Acinetobacter baumannii: description of a hybrid class 2 integron. Ploy, M.C., Denis, F., Courvalin, P., Lambert, T. Antimicrob. Agents Chemother. (2000) [Pubmed]
  2. Cloning and characterization of a 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ib, from Pseudomonas aeruginosa. Schwocho, L.R., Schaffner, C.P., Miller, G.H., Hare, R.S., Shaw, K.J. Antimicrob. Agents Chemother. (1995) [Pubmed]
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