Disease relevance of XK 70-1

• Astromicin-induced membrane damage in Serratia marcescens [1].
• Analysis of the self-defense gene (fmrO) of a fortimicin A (astromicin) producer, Micromonospora olivasterospora: comparison with other aminoglycoside-resistance-encoding genes [2].
• Synergistic activity of astromicin and beta-lactam antibiotics against Pseudomonas aeruginosa in vitro and in vivo [3].
• Enzymatic modification using cell free extracts from Streptomyces lividans TK21/pANT-S2 carrying the cloned gene revealed that the gene coded for an AG 6'-acetyltransferase [AAC(6')] capable of acetylating all of the tested AGs with 6'-NH2 including semisynthetic ones and astromicin [4].

High impact information on XK 70-1

• Intragenic probes specific for either aac(3)-Ia or aac(3)-Ib were used in hybridization studies with a series of gentamicin-, astromicin-, and sisomicin-resistant clinical isolates [5].
• The nucleotide (nt) sequence of a 3409-bp PvuII fragment carrying the self-defense gene (fmrO) of a fortimicin A (FmA; astromicin) producer, Micromonospora olivasterospora, was determined; four open reading frames (ORFs) exist in this region [2].
• Organization and nature of fortimicin A (astromicin) biosynthetic genes studied using a cosmid library of Micromonospora olivasterospora DNA [6].
• Dactimicin is a new pseudo-disaccharide aminoglycoside, originally isolated from cultures of Dactylosporangium matsuzakienzae sp. nov., which is chemically related to astromicin [7].
• The effect of dactimicin on the inner ear of guinea pigs was investigated by comparing it with the effects of ribostamycin, astromicin and amikacin [8].

Chemical compound and disease context of XK 70-1

• The combination of astromicin with piperacillin showed a bactericidal activity against Pseudomonas aeruginosa at a bacteriostatic concentration of each antibiotic alone [3].
• An inosamine-idiotrophic mutant, KY11559, which produced no astromicin unless scyllo-inosamine was added to the fermentation medium, was isolated from Micromonospora olivasterospora [9].

Biological context of XK 70-1

• Acetylation of astromicin by the aminoglycoside 6'-N-acetyltransferase of a gentamicin-resistant S. aureus [10].

Associations of XK 70-1 with other chemical compounds

• Urinary N-acetyl-beta-glucosaminidase (NAG) activity was determined in ten patients receiving 200 mg of astromicin and ten patients receiving 100 mg of dibekacin; each dose was administered twice a day for five days [11].

Analytical, diagnostic and therapeutic context of XK 70-1

• A fluorescence polarization immunoassay evaluated for quantifying astromicin, a new aminoglycoside antibiotic [12].
• The morphological changes in Serratia marcescens induced by astromicin were determined by a new technique of electron microscopy, a rapid freezing and substitution fixation technique, and a freeze-fracturing technique [1].
• Washed mycelia of M. olivasterospora mutants converted these compounds to astromicin, which was detected by thin-layer chromatography [13].

References