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Chemical Compound Review

Sisomicin sulfate     2-[4,6-diamino-3-[[3-amino-6- (aminomethyl)...

Synonyms: SPBio_002352, AC1L1JVF, STK249709, AR-1F8589, AC1Q57V9, ...
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Disease relevance of sisomicin


High impact information on sisomicin


Chemical compound and disease context of sisomicin


Biological context of sisomicin


Anatomical context of sisomicin

  • Sisomicin in urinary tract infection: Tolerance and efficacy study [20].
  • One hour after subconjunctival injection, highly therapeutic sisomicin concentrations were achieved in the aqueous humor of both injected and fellow eyes, but the level dropped to very low concentrations 12 hours after the injection [21].
  • When the negative charges of the carboxyl groups of the peptidoglycans are changed to neutral or positive charges, sisomicin does not bind to the cell wall [22].
  • This paper reports on a dynamic study of the morphological changes within the cochlear and vestibular ganglia of the guinea pig after local application of Sisomicin in the inner ear [23].
  • When dams were treated with 25 mg/kg during weeks 1-5 of pregnancy, fetal sisomicin concentration in the kidneys was 9 times greater than in the cochlea; in 3-week-old animals, a drug concentration of 4 microgram/g was detected only in the kidneys [24].

Associations of sisomicin with other chemical compounds


Gene context of sisomicin


Analytical, diagnostic and therapeutic context of sisomicin


  1. Qualitative overview of randomized trials of aminoglycosides. Evans, D.A., Buring, J., Mayrent, S., Rosner, B., Colton, T., Hennekens, C. Am. J. Med. (1986) [Pubmed]
  2. Cloning and characterization of a 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ib, from Pseudomonas aeruginosa. Schwocho, L.R., Schaffner, C.P., Miller, G.H., Hare, R.S., Shaw, K.J. Antimicrob. Agents Chemother. (1995) [Pubmed]
  3. Semisynthetic aminoglycoside antibacterials. 6. Synthesis of sisomicin, Antibiotic G-52, and novel 6'-substituted analogues of sisomicin from aminoglycoside 66-40C. Davies, D.H., Mallams, A.K., Counelis, M., Loebenberg, D., Moss, E.L., Waitz, J.A. J. Med. Chem. (1978) [Pubmed]
  4. Experimental osteomyelitis. V. Therapeutic trials with oxacillin and sisomicin alone and in combination. Norden, C.W. J. Infect. Dis. (1978) [Pubmed]
  5. Aminoglycosides modify the in vitro metachromatic reaction and murine generalized Shwartzman phenomenon induced by Salmonella minnesota R595 lipopolysaccharide. Focà, A., Matera, G., Iannello, D., Berlinghieri, M.C., Liberto, M.C. Antimicrob. Agents Chemother. (1991) [Pubmed]
  6. Kinetic mechanisms of gentamicin acetyltransferase I. Antibiotic-dependent shift from rapid to nonrapid equilibrium random mechanisms. Williams, J.W., Northrop, D.B. J. Biol. Chem. (1978) [Pubmed]
  7. Cloning and DNA sequence analysis of an aac(3)-Vb gene from Serratia marcescens. Rather, P.N., Mierzwa, R., Hare, R.S., Miller, G.H., Shaw, K.J. Antimicrob. Agents Chemother. (1992) [Pubmed]
  8. Experimental osteomyelitis caused by Pseudomonas aeruginosa. Norden, C.W., Keleti, E. J. Infect. Dis. (1980) [Pubmed]
  9. High-level, plasmid-borne resistance to gentamicin in Streptococcus faecalis subsp. zymogenes. Horodniceanu, T., Bougueleret, L., El-Solh, N., Bieth, G., Delbos, F. Antimicrob. Agents Chemother. (1979) [Pubmed]
  10. In vitro susceptibility of recently isolated gram-negative bacteria to gentamicin, sisomicin, tobramycin, and amikacin. Knothe, H. J. Infect. Dis. (1976) [Pubmed]
  11. Experimental osteomyelitis. IV. Therapeutic trials with rifampin alone and in combination with gentamicin, sisomicin, and cephalothin. Norden, C.W. J. Infect. Dis. (1975) [Pubmed]
  12. Ceftazidime monotherapy vs. combined therapy in Pseudomonas pulmonary infections in cystic fibrosis. Padoan, R., Cambisano, W., Costantini, D., Crossignani, R.M., Danza, M.L., Trezzi, G., Giunta, A. Pediatr. Infect. Dis. J. (1987) [Pubmed]
  13. Combined action of decreasing concentrations of azlocillin and sisomicin on Pseudomonas aeruginosa as assessed in a dynamic in vitro model. Haller, I. Infection (1982) [Pubmed]
  14. Interactions between mezlocillin and sisomicin in vitro and in patients with normal and various degrees of impaired renal function. Kampf, D., Schurig, R., Bergs, A., Förster, D. Clin. Nephrol. (1983) [Pubmed]
  15. Pharmacokinetics of sisomicin in patients with normal and impaired renal function; its efficacy in urinary tract infection. Roth, S., Naber, K., Scheer, M., Gruenwaldt, G., Lange, H. Eur. J. Clin. Pharmacol. (1976) [Pubmed]
  16. Clinical pharmacokinetics of sisomicin: dosage schedules in renal-impaired patients. Pechère, J.C., Pechère, M.M., Dugal, R. Antimicrob. Agents Chemother. (1976) [Pubmed]
  17. Clinical pharmacology of sisomicin. Rodriguez, V., Bodey, G.P., Valdivieso, M., Feld, R. Antimicrob. Agents Chemother. (1975) [Pubmed]
  18. Aqueous kinetics of sisomicin sulphate. Desai, S., Desai, R., Bhatt, V., Sharma, R. Eye (London, England) (1992) [Pubmed]
  19. Biotransformation, a new approach to aminoglycoside biosynthesis. I. Sisomicin. Testa, R.T., Tilley, B.C. J. Antibiot. (1975) [Pubmed]
  20. Sisomicin in urinary tract infection: Tolerance and efficacy study. Etra, W., Surgalla, M., Wajsman, Z., Baumgartner, G., Merrin, C. Urology (1976) [Pubmed]
  21. Intraocular penetration of sisomicin in rabbits. Faris, B.M., Fahd, S., Khuri, G., Kuraydiyyah, I., Uwaydah, M. Arch. Ophthalmol. (1980) [Pubmed]
  22. Analysis of sisomicin binding sites in Micromonospora inyoensis cell wall. Kim, D.H., Suh, J.H., Ju, J.Y., Yum, S.K., Shin, C.S. FEMS Microbiol. Lett. (1998) [Pubmed]
  23. Neuronal degeneration of primary cochlear and vestibular innervations after local injection of sisomicin in the guinea pig. Dupont, J., Guilhaume, A., Aran, J.M. Hear. Res. (1993) [Pubmed]
  24. Transfer of sisomicin to unborn and suckling guinea pigs. Matsuzawa, T., Nakata, M., Ikeda, C., Tachibana, A., Yano, K. Chemotherapy. (1981) [Pubmed]
  25. In vitro comparison of netilmicin, a semisynthetic derivative of sisomicin, and four other aminoglycoside antibiotics. Kabins, S.A., Nathan, C., Cohen, S. Antimicrob. Agents Chemother. (1976) [Pubmed]
  26. Determination of sisomicin, netilmicin, astromicin and micronomicin in serum by high-performance liquid chromatography. Kawamoto, T., Mashimo, I., Yamauchi, S., Watanabe, M. J. Chromatogr. (1984) [Pubmed]
  27. The combined action of azlocillin and sisomicin in a model simulating the in vivo serum kinetics. Haller, I. Infection (1983) [Pubmed]
  28. Activity and synergy of ureido penicillins and aminoglycosides against Pseudomonas aeruginosa. Hoogkamp-Korstanje, J.A., Westerdaal, N.A. Infection (1982) [Pubmed]
  29. Comparative study of the binding of acylureidopenicillins and carbenicillin to human serum proteins. Rosenkranz, H., Förster, D. Infection (1979) [Pubmed]
  30. Assay of aminoglycoside antibiotics in clinical specimens. Giamarellou, H., Zimelis, V.M., Matulionis, D.O., Jackson, G.G. J. Infect. Dis. (1975) [Pubmed]
  31. Binding of aminoglycoside antibiotics to human serum proteins. III. Effect of experimental conditions. Rosenkranz, H., Scheer, M., Scholtan, W. Infection (1978) [Pubmed]
  32. Analysis of the aac(3)-VIa gene encoding a novel 3-N-acetyltransferase. Rather, P.N., Mann, P.A., Mierzwa, R., Hare, R.S., Miller, G.H., Shaw, K.J. Antimicrob. Agents Chemother. (1993) [Pubmed]
  33. Persistence of sisomicin and gentamicin in renal cortex and medulla compared with other organs and serum of rats. Fabre, J., Rudhardt, M., Blanchard, P., Regamey, C. Kidney Int. (1976) [Pubmed]
  34. Radioimmunoassay of sisomicin. Broughton, A., Strong, J.E., Bodey, G.P. Antimicrob. Agents Chemother. (1976) [Pubmed]
  35. Comparative study of three routes of administration of sisomicin. Meunier-Carpentier, F., Staquet, M., Klastersky, J. Journal of clinical pharmacology. (1976) [Pubmed]
  36. Pre-column derivatization of sisomicin with o-phthalaldehyde-beta-mercaptopropionic acid and its application to sensitive high-performance liquid chromatographic determination with fluorimetric detection. Tawa, R., Koshide, K., Hirose, S., Fujimoto, T. J. Chromatogr. (1988) [Pubmed]
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