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Gene Review:

tas - ORF1/Tas/Bel1

Equine foamy virus

German, A.C. et al., Meiering, C.D. et al., Kang, Y. et al.

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Disease relevance of tas

Use of specific probes has also shown that a majority of the proviruses contain the complete tas gene, which encodes the viral transactivator, and are not derived from Deltatas cDNAs, which have been shown to arise rapidly in infected cells [1].
Derivation and functional characterization of a consensus DNA binding sequence for the tas transcriptional activator of simian foamy virus type 1 [2].
The generation of infectious virions using these cell lines has been investigated using tas-deleted FFV vectors containing the enhanced green fluorescent protein (eGFP) cassette [3].

High impact information on tas

Stable helper cell line clones have been established by transfection of CRFK cells with FFV tas and assessed using beta-galactosidase assays, PCR, immunofluorescence and western blotting [3].

References

Multiple integrations of human foamy virus in persistently infected human erythroleukemia cells. Meiering, C.D., Comstock, K.E., Linial, M.L. J. Virol. (2000) [Pubmed]
Derivation and functional characterization of a consensus DNA binding sequence for the tas transcriptional activator of simian foamy virus type 1. Kang, Y., Cullen, B.R. J. Virol. (1998) [Pubmed]
FIP: a novel approach to vaccination. Proceedings from the 2nd International FCoV/FIP Symposium, Glasgow, 4-7 August 2002. German, A.C., Helps, C.R., Harbour, D.A. J. Feline Med. Surg. (2004) [Pubmed]

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