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Gene Review:

SUS1 - Sus1p

Saccharomyces cerevisiae S288c

Synonyms: Transcription and mRNA export factor SUS1, YBR111W-A

Rodríguez-Navarro, S. et al., Römer, U. et al.

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High impact information on SUS1

Biochemical analyses show that Sus1 interacts with SAGA, a large intranuclear histone acetylase complex involved in transcription initiation, and with the Sac3-Thp1 complex, which functions in mRNA export with specific nuclear pore proteins at the nuclear basket [1].
Sus1 is a nuclear protein with a concentration at the nuclear pores [1].
Moreover, chromatin immunoprecipitation showed that Sus1 is associated with the promoter of a SAGA-dependent gene during transcription activation [1].
The gene sus1 from Solanum tuberosum L. encoding for sucrose synthase 1 was cloned into the plasmid pDR195 under the control of the PMA1 promotor [2].

References

Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery. Rodríguez-Navarro, S., Fischer, T., Luo, M.J., Antúnez, O., Brettschneider, S., Lechner, J., Pérez-Ortín, J.E., Reed, R., Hurt, E. Cell (2004) [Pubmed]
Expression, purification and characterization of recombinant sucrose synthase 1 from Solanum tuberosum L. for carbohydrate engineering. Römer, U., Schrader, H., Günther, N., Nettelstroth, N., Frommer, W.B., Elling, L. J. Biotechnol. (2004) [Pubmed]

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