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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Solanum

  • A cDNA encoding potato (Solanum tuberosum L.) 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, the first enzyme of the shikimate pathway, was cloned into phage lambda gt11 [1].
  • Expression of Escherichia coli glycogen synthase in the tubers of transgenic potatoes (Solanum tuberosum) results in a highly branched starch [2].
  • To investigate the regulation of this branch point, we engineered TS antisense potato (Solanum tuberosum cv Désirée) plants using the constitutive cauliflower mosaic virus 35S promoter [3].
  • We investigated the inhibitory effect of eggplant (Solanum melongena var. marunasu) extract on human fibrosarcoma HT-1080 cell invasion of reconstituted basement membrane [Matrigel (MG)] [4].
  • The effect of a commercial Lactobacillus starter and sodium chloride concentration on the fermentation of "Almagro" eggplants (Solanum melongena L. var. esculentum depressum) was studied [5].

High impact information on Solanum

  • RAX1 is encoded by the Myb-like transcription factor MYB37 and is an Arabidopsis homolog of the tomato (Solanum lycopersicum) Blind gene [6].
  • In this study, we present evidence implicating SlNAC1, a new member of the NAC domain protein family from tomato (Solanum lycopersicum), in Tomato leaf curl virus (TLCV) REn function [7].
  • We report here that the downregulation of IAA9, a tomato (Solanum lycopersicum) gene from a distinct subfamily of Aux/IAA genes, results in a pleiotropic phenotype, consistent with its ubiquitous expression pattern [8].
  • In this study, we investigate the influence of a decreased expression of UMP synthase (UMPS), a key enzyme in the pathway of de novo pyrimidine synthesis, on biosynthetic processes in growing potato (Solanum tuberosum) tubers [9].
  • Transgenic downregulation of PHAN in the compound tomato (Solanum lycopersicum) leaf results in an abaxialized rachis without leaflets [10].

Chemical compound and disease context of Solanum


Biological context of Solanum


Anatomical context of Solanum


Associations of Solanum with chemical compounds

  • Lipid-derived signals that discriminate wound- and pathogen-responsive isoprenoid pathways in plants: methyl jasmonate and the fungal elicitor arachidonic acid induce different 3-hydroxy-3-methylglutaryl-coenzyme A reductase genes and antimicrobial isoprenoids in Solanum tuberosum L [25].
  • The potato tuber (Solanum tuberosum L.) ADP-glucose pyrophosphorylase (ADP-GlcPPase) catalyzes the first committed step in starch biosynthesis [26].
  • Identification and characterization of a novel plastidic adenine nucleotide uniporter from Solanum tuberosum [15].
  • Malate dehydrogenase (decarboxylating) (EC was purified to near homogeneity from both a C3 plant, Solanum tuberosum, and a CAM plant, Crassula argentea [27].
  • The sulfated glycosaminoglycans, such as keratan sulfate and chitin sulfate having 3-hydroxy free N-acetyl-beta-D-glucosaminyl residues as constituents, reacted with wheat germ agglutinin and Solanum tuberosum agglutinin by sugar-specific interaction [28].

Gene context of Solanum

  • We adopted a leaf disc system for monitoring the effects of various conditions on G6PD isoform expression and enzyme activities in potato (Solanum tuberosum) [29].
  • Expression of the tomato (Solanum lycopersicum) CRY2 gene was altered through a combination of transgenic overexpression and virus-induced gene silencing [30].
  • Reactivity with antibodies against the Le(b) structure (where Le represents the Lewis antigen) followed the MUC5AC distribution, whereas antibodies against the Le(y) structure and reactivity with the GlcNAc-selective Solanum tuberosum lectin coincided with MUC6, suggesting that the two mucins are glycosylated differently [31].
  • The LKT1 channel is a member of the AKT family of K+(in) channels previously identified in Arabidopsis thaliana (L.) Heynh. and potato (Solanum tuberosum L.). Moreover, LKT1 is closely related (97% identical amino acids) to potato SKT1 [32].
  • The mother tincture of Solanum dulcamara inhibited the production of PGE2 by COX 1 (IC50 40 microg/ml) and COX 2 (IC50 150 microg/ml) but not production of leukotriene LTB4 by 5-LOX [33].

Analytical, diagnostic and therapeutic context of Solanum

  • Potato lectin (Solanum tuberosum agglutinin, STA), purified by affinity chromatography on tri-N-acetylchitotriose-Sepharose 6B, has Mr approximately 100,000, as estimated by gel filtration on Sephadex G-150 and is an aggregating system with a monomer Mr = 54,000, as estimated by sedimentation equilibrium analysis [34].
  • We report the molecular cloning of a cDNA (StFum-1) that encodes fumarase from potato (Solanum tuberosum L.). RNA blot analysis demonstrated that StFum-1 is most strongly expressed in flowers, immature leaves, and tubers [35].
  • A cDNA clone of unknown function, DEA1, was isolated from arachidonic acid-treated tomato (Solanum lycopersicum) leaves by differential display PCR [36].
  • Isolated potato (Solanum tuberosum) tuber mitochondria purified by isopycnic centrifugation in density gradients of Percoll were found to be highly intact, to be devoid of extramitochondrial contaminations and to retain a high rate of O2 consumption [37].
  • An anionic peroxidase (EC, thought to be involved in suberization, was purified 110-fold from wound-healing slices of Solanum tuberosum by a combination of ammonium sulfate fractionation, Sephadex G-100 gel filtration, isoelectric focusing, and phenyl-Sepharose CL-4B chromatography in 24% yield [38].


  1. A cDNA encoding 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Solanum tuberosum L. Dyer, W.E., Weaver, L.M., Zhao, J.M., Kuhn, D.N., Weller, S.C., Herrmann, K.M. J. Biol. Chem. (1990) [Pubmed]
  2. Expression of Escherichia coli glycogen synthase in the tubers of transgenic potatoes (Solanum tuberosum) results in a highly branched starch. Shewmaker, C.K., Boyer, C.D., Wiesenborn, D.P., Thompson, D.B., Boersig, M.R., Oakes, J.V., Stalker, D.M. Plant Physiol. (1994) [Pubmed]
  3. Antisense inhibition of threonine synthase leads to high methionine content in transgenic potato plants. Zeh, M., Casazza, A.P., Kreft, O., Roessner, U., Bieberich, K., Willmitzer, L., Hoefgen, R., Hesse, H. Plant Physiol. (2001) [Pubmed]
  4. Inhibitory effect of delphinidin from Solanum melongena on human fibrosarcoma HT-1080 invasiveness in vitro. Nagase, H., Sasaki, K., Kito, H., Haga, A., Sato, T. Planta Med. (1998) [Pubmed]
  5. Influence of sodium chloride concentration on the controlled lactic acid fermentation of "Almagro" eggplants. Ballesteros, C., Palop, L., Sánchez, I. Int. J. Food Microbiol. (1999) [Pubmed]
  6. Arabidopsis REGULATOR OF AXILLARY MERISTEMS1 controls a leaf axil stem cell niche and modulates vegetative development. Keller, T., Abbott, J., Moritz, T., Doerner, P. Plant Cell (2006) [Pubmed]
  7. A NAC domain protein interacts with tomato leaf curl virus replication accessory protein and enhances viral replication. Selth, L.A., Dogra, S.C., Rasheed, M.S., Healy, H., Randles, J.W., Rezaian, M.A. Plant Cell (2005) [Pubmed]
  8. The tomato Aux/IAA transcription factor IAA9 is involved in fruit development and leaf morphogenesis. Wang, H., Jones, B., Li, Z., Frasse, P., Delalande, C., Regad, F., Chaabouni, S., Latché, A., Pech, J.C., Bouzayen, M. Plant Cell (2005) [Pubmed]
  9. Inhibition of de novo pyrimidine synthesis in growing potato tubers leads to a compensatory stimulation of the pyrimidine salvage pathway and a subsequent increase in biosynthetic performance. Geigenberger, P., Regierer, B., Nunes-Nesi, A., Leisse, A., Urbanczyk-Wochniak, E., Springer, F., van Dongen, J.T., Kossmann, J., Fernie, A.R. Plant Cell (2005) [Pubmed]
  10. The mutant crispa reveals multiple roles for PHANTASTICA in pea compound leaf development. Tattersall, A.D., Turner, L., Knox, M.R., Ambrose, M.J., Ellis, T.H., Hofer, J.M. Plant Cell (2005) [Pubmed]
  11. Enhanced cystathionine beta-lyase activity in transgenic potato plants does not force metabolite flow towards methionine. Maimann, S., Hoefgen, R., Hesse, H. Planta (2001) [Pubmed]
  12. Effects of Solanum malacoxylon extract on rachitic chicks. Comparative study with vitamin D3. Cañas, F.M., Ortiz, O.E., Asteggiano, C.A., Pereira, R.D. Calcified tissue research. (1977) [Pubmed]
  13. Antiulcerogenic and ulcer healing effects of Solanum nigrum (L.) on experimental ulcer models: possible mechanism for the inhibition of acid formation. Jainu, M., Devi, C.S. Journal of ethnopharmacology. (2006) [Pubmed]
  14. Accidental mydriasis from blue nightshade "lipstick". Rubinfeld, R.S., Currie, J.N. Journal of clinical neuro-ophthalmology. (1987) [Pubmed]
  15. Identification and characterization of a novel plastidic adenine nucleotide uniporter from Solanum tuberosum. Leroch, M., Kirchberger, S., Haferkamp, I., Wahl, M., Neuhaus, H.E., Tjaden, J. J. Biol. Chem. (2005) [Pubmed]
  16. Expression of cysteine proteinase during developmental events associated with programmed cell death in brinjal. Xu, F.X., Chye, M.L. Plant J. (1999) [Pubmed]
  17. Overexpression of a knotted-like homeobox gene of potato alters vegetative development by decreasing gibberellin accumulation. Rosin, F.M., Hart, J.K., Horner, H.T., Davies, P.J., Hannapel, D.J. Plant Physiol. (2003) [Pubmed]
  18. Heterologous expression of Arabidopsis phytochrome B in transgenic potato influences photosynthetic performance and tuber development. Thiele, A., Herold, M., Lenk, I., Quail, P.H., Gatz, C. Plant Physiol. (1999) [Pubmed]
  19. The phytochrome gene family in tomato and the rapid differential evolution of this family in angiosperms. Alba, R., Kelmenson, P.M., Cordonnier-Pratt, M.M., Pratt, L.H. Mol. Biol. Evol. (2000) [Pubmed]
  20. One-step generation of cytoplasmic male sterility by fusion of mitochondrial-inactivated tomato protoplasts with nuclear-inactivated Solanum protoplasts. Melchers, G., Mohri, Y., Watanabe, K., Wakabayashi, S., Harada, K. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  21. Expression analysis suggests novel roles for the plastidic phosphate transporter Pht2;1 in auto- and heterotrophic tissues in potato and Arabidopsis. Rausch, C., Zimmermann, P., Amrhein, N., Bucher, M. Plant J. (2004) [Pubmed]
  22. Analysis of the involvement of ocs-like bZip-binding elements in the differential strength of the bidirectional mas1'2' promoter. Feltkamp, D., Masterson, R., Starke, J., Rosahl, S. Plant Physiol. (1994) [Pubmed]
  23. Electrophoresis-related protein modification: alkylation of carboxy residues revealed by mass spectrometry. Haebel, S., Albrecht, T., Sparbier, K., Walden, P., Körner, R., Steup, M. Electrophoresis (1998) [Pubmed]
  24. Isolation of a lectin from the pericarp of potato (Solanum tuberosum) fruits. Kilpatrick, D.C. Biochem. J. (1980) [Pubmed]
  25. Lipid-derived signals that discriminate wound- and pathogen-responsive isoprenoid pathways in plants: methyl jasmonate and the fungal elicitor arachidonic acid induce different 3-hydroxy-3-methylglutaryl-coenzyme A reductase genes and antimicrobial isoprenoids in Solanum tuberosum L. Choi, D., Bostock, R.M., Avdiushko, S., Hildebrand, D.F. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  26. Activation of the potato tuber ADP-glucose pyrophosphorylase by thioredoxin. Ballicora, M.A., Frueauf, J.B., Fu, Y., Schürmann, P., Preiss, J. J. Biol. Chem. (2000) [Pubmed]
  27. Evidence for a multiple subunit composition of plant NAD malic enzyme. Willeford, K.O., Wedding, R.T. J. Biol. Chem. (1987) [Pubmed]
  28. Interaction of sulfated glycosaminoglycans with lectins. Toda, N., Doi, A., Jimbo, A., Matsumoto, I., Seno, N. J. Biol. Chem. (1981) [Pubmed]
  29. Differential regulation of glucose-6-phosphate dehydrogenase isoenzyme activities in potato. Hauschild, R., von Schaewen, A. Plant Physiol. (2003) [Pubmed]
  30. Manipulation of the blue light photoreceptor cryptochrome 2 in tomato affects vegetative development, flowering time, and fruit antioxidant content. Giliberto, L., Perrotta, G., Pallara, P., Weller, J.L., Fraser, P.D., Bramley, P.M., Fiore, A., Tavazza, M., Giuliano, G. Plant Physiol. (2005) [Pubmed]
  31. Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution. Nordman, H., Davies, J.R., Lindell, G., de Bolós, C., Real, F., Carlstedt, I. Biochem. J. (2002) [Pubmed]
  32. Functional characterisation of LKT1, a K+ uptake channel from tomato root hairs, and comparison with the closely related potato inwardly rectifying K+ channel SKT1 after expression in Xenopus oocytes. Hartje, S., Zimmermann, S., Klonus, D., Mueller-Roeber, B. Planta (2000) [Pubmed]
  33. Dual inhibition of 5-lipoxygenase/cyclooxygenase by a reconstituted homeopathic remedy; possible explanation for clinical efficacy and favourable gastrointestinal tolerability. Jäggi, R., Würgler, U., Grandjean, F., Weiser, M. Inflamm. Res. (2004) [Pubmed]
  34. Purification and characterization of potato lectin. Matsumoto, I., Jimbo, A., Mizuno, Y., Seno, N., Jeanloz, R.W. J. Biol. Chem. (1983) [Pubmed]
  35. Molecular characterization of potato fumarate hydratase and functional expression in Escherichia coli. Nast, G., Müller-Röber, B. Plant Physiol. (1996) [Pubmed]
  36. A circadian rhythm-regulated tomato gene is induced by Arachidonic acid and Phythophthora infestans infection. Weyman, P.D., Pan, Z., Feng, Q., Gilchrist, D.G., Bostock, R.M. Plant Physiol. (2006) [Pubmed]
  37. Slow passive diffusion of NAD+ between intact isolated plant mitochondria and suspending medium. Neuburger, M., Douce, R. Biochem. J. (1983) [Pubmed]
  38. Purification and characterization of an abscisic acid-inducible anionic peroxidase associated with suberization in potato (Solanum tuberosum). Espelie, K.E., Kolattukudy, P.E. Arch. Biochem. Biophys. (1985) [Pubmed]
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