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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CFAP52  -  cilia and flagella associated protein 52

Homo sapiens

Synonyms: Cilia-and flagella-associated protein 52, FLJ37528, WD repeat-containing protein 16, WD40-repeat protein up-regulated in HCC, WDR16, ...
 
 
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Disease relevance of WDR16

  • Biosynthesis of Wdr16, a marker protein for kinocilia-bearing cells, starts at the time of kinocilia formation in rat, and wdr16 gene knockdown causes hydrocephalus in zebrafish [1].
 

High impact information on WDR16

  • The rat ortholog of the WD40 repeat protein Wdr16 is abundantly expressed in testis and cultured ependymal cells [1].
  • In testis, ependyma and respiratory epithelium, the Wdr16 protein is up-regulated together with kinocilia formation [1].
  • In testis and ependymal primary cultures, Wdr16 messenger RNA appears concomitantly with the messages for sperm-associated antigen 6, a kinocilia marker, and for hydin, a protein linked to ciliary function and hydrocephalus [1].
  • Transfection of plasmids designed to express WDRPUH-specific siRNA significantly reduced its expression in HCC cells and resulted in growth suppression of transfected cells [2].

References

  1. Biosynthesis of Wdr16, a marker protein for kinocilia-bearing cells, starts at the time of kinocilia formation in rat, and wdr16 gene knockdown causes hydrocephalus in zebrafish. Hirschner, W., Pogoda, H.M., Kramer, C., Thiess, U., Hamprecht, B., Wiesmüller, K.H., Lautner, M., Verleysdonk, S. J. Neurochem. (2007) [Pubmed]
  2. WDRPUH, a novel WD-repeat-containing protein, is highly expressed in human hepatocellular carcinoma and involved in cell proliferation. Silva, F.P., Hamamoto, R., Nakamura, Y., Furukawa, Y. Neoplasia (2005) [Pubmed]
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