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Gene Review

CSTF3  -  cleavage stimulation factor, 3' pre-RNA,...

Homo sapiens

Synonyms: CF-1 77 kDa subunit, CSTF 77 kDa subunit, Cleavage stimulation factor 77 kDa subunit, Cleavage stimulation factor subunit 3, CstF-77
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High impact information on CSTF3

  • Crystal Structure of Murine CstF-77: Dimeric Association and Implications for Polyadenylation of mRNA Precursors [1].
  • The mode of dimerization and the relative arrangement of the HAT-N and HAT-C domains are unique to CstF-77 [1].
  • In CstF-64, a small region, highly conserved in metazoa, is responsible for interactions with two proteins, CstF-77 and symplekin, a nuclear protein of previously unknown function [2].
  • We therefore first identified regions of the CstF subunits, CstF-77, CstF-64, and CstF-50, required for interaction with each other [2].
  • In CstF-77, a proline-rich domain is necessary not only for binding both other subunits but also for self-association, an interaction consistent with genetic studies in Drosophila [2].

Biological context of CSTF3

  • By both bioinformatic searches and validation with molecular biology experiments, we found that human and mouse CstF-77 genes also contain an intronic poly(A) site, which can be utilized to produce short CstF-77 transcripts lacking sequences encoding domains that are involved in many of the CstF-77 functions [3].

Anatomical context of CSTF3

  • Features of mtauCstF-64 that might allow it to promote the germ cell pattern of polyadenylation include a Pro --> Ser substitution in the RNA-binding domain and significant changes in the region that interacts with CstF-77 [4].

Analytical, diagnostic and therapeutic context of CSTF3


  1. Crystal Structure of Murine CstF-77: Dimeric Association and Implications for Polyadenylation of mRNA Precursors. Bai, Y., Auperin, T.C., Chou, C.Y., Chang, G.G., Manley, J.L., Tong, L. Mol. Cell (2007) [Pubmed]
  2. Complex protein interactions within the human polyadenylation machinery identify a novel component. Takagaki, Y., Manley, J.L. Mol. Cell. Biol. (2000) [Pubmed]
  3. An intronic polyadenylation site in human and mouse CstF-77 genes suggests an evolutionarily conserved regulatory mechanism. Pan, Z., Zhang, H., Hague, L.K., Lee, J.Y., Lutz, C.S., Tian, B. Gene (2006) [Pubmed]
  4. The gene for a variant form of the polyadenylation protein CstF-64 is on chromosome 19 and is expressed in pachytene spermatocytes in mice. Dass, B., McMahon, K.W., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., MacDonald, C.C. J. Biol. Chem. (2001) [Pubmed]
  5. The use of in situ proteolysis in the crystallization of murine CstF-77. Bai, Y., Auperin, T.C., Tong, L. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2007) [Pubmed]
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