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SYMPK  -  symplekin

Homo sapiens

Synonyms: SPK, SYM, Symplekin
 
 
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Disease relevance of SYMPK

 

Psychiatry related information on SYMPK

 

High impact information on SYMPK

  • Symplekin and multiple other polyadenylation factors participate in 3'-end maturation of histone mRNAs [6].
  • Reconstitution experiments reveal that symplekin, previously shown to be necessary for cytoplasmic poly(A) tail elongation and translational activation of mRNAs during Xenopus oocyte maturation, is the essential heat-labile component [6].
  • Junctional plaque proteins without known functions include cingulin, p130, and 7H6; single reports describe ZA-1TJ and symplekin [7].
  • Symplekin, a novel type of tight junction plaque protein [8].
  • We discuss symplekin as a representative of a group of dual residence proteins which occur and probably function in the nucleus as well as in the plaques exclusive for either tight junctions, adherens junctions, or desmosomes [8].
 

Biological context of SYMPK

  • These results indicate that the HSF1-symplekin interaction functions as a mechanism for recruiting polyadenylation factors to HSP genes to enhance the efficiency/kinetics of production of mature Hsp mRNA transcripts to achieve the critical cellular need for rapid HSP expression after stress [9].
  • Exon trapping from cosmids mapping to chromosome 19q13.3 yielded 6 exonic sequences that matched the human symplekin gene, which encodes a tight junction-related protein [10].
  • Rice SPK, a calmodulin-like domain protein kinase, is required for storage product accumulation during seed development: phosphorylation of sucrose synthase is a possible factor [11].
  • As a result of this combined experience, it is not unexpected then that we observe significantly improved graft survival rates in MMF-treated SPK patients compared with patients receiving a more traditional immunosuppressive regimen [12].
  • The 5' terminal sequences of both genome RNA species of TRV strains ORY, N5 and PRN together with that of SYM RNA-2 were also determined [13].
 

Anatomical context of SYMPK

 

Associations of SYMPK with chemical compounds

  • The kainate agonist SYM 2081, was used to confirm the presence of kainate receptors [17].
  • The sAT was more sensitive and specific than GAO and as sensitive as creatinine for SPK recipients [18].
  • Channels activated by glutamate or SYM 2081 exhibited conductance levels of 2-20 pS [17].
  • CONCLUSIONS: CMV disease recurs in roughly one-third of KTx and SPK recipients after treatment of the initial episode with ganciclovir [19].
  • CONCLUSIONS: Based on risk and extrapolating from the general surgical literature, our recommendations for prophylaxis against DVT are use of graduated compression stockings for all recipients and, in addition, low-dose heparin for moderate and high-risk recipients (previous DVT, SPK, age > 40 years, DM) [1].
 

Other interactions of SYMPK

  • HSF1-symplekin complexes are detected only after stress treatment, and these two proteins co-localize in punctate nuclear structures in stressed cells [9].
  • HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin [9].
  • Our data thus indicate that symplekin and ZONAB/DbpA cooperate in the regulation of transcription, and that they promote epithelial proliferation and cyclin D1 expression [14].
 

Analytical, diagnostic and therapeutic context of SYMPK

  • METHODS: A retrospective comparison of 358 consecutive primary SPK transplantations performed from 1990 to 1997 was conducted [12].
  • BACKGROUND: In simultaneous kidney-pancreas (SPK) transplantation, manifestations of renal allograft rejection typically become evident before those of pancreatic rejection [20].
  • CONCLUSIONS: This retrospective study demonstrates that MMF is a highly effective immunosuppressant in SPK transplantation [12].
  • The serum levels of pre-existent ICAS in diabetic patients undergoing SPK with immunosuppression were not reduced, and they did not interfere with the function of the implanted pancreas over a period of 60 days [21].
  • CONCLUSIONS: Eligible IDDM patients with advanced diabetic nephropathy should choose SPK over kidney transplantation alone from either a cadaver or a living source [22].

References

  1. Venous thromboembolic complications after kidney and kidney-pancreas transplantation: a multivariate analysis. Humar, A., Johnson, E.M., Gillingham, K.J., Sutherland, D.E., Payne, W.D., Dunn, D.L., Wrenshall, L.E., Najarian, J.S., Gruessner, R.W., Matas, A.J. Transplantation (1998) [Pubmed]
  2. Improvements in diabetic microangiopathy after successful simultaneous pancreas-kidney transplantation: a computer-assisted intravital microscopy study on the conjunctival microcirculation. Cheung, A.T., Perez, R.V., Chen, P.C. Transplantation (1999) [Pubmed]
  3. The utility of retroperitoneal kidney placement in simultaneous kidney pancreas transplantation. Kuo, P.C., Krieger, N.R., Alfrey, E.J., Scandling, J., Dafoe, D.C. Clinical transplantation. (1995) [Pubmed]
  4. A comparison of therapeutic regimens containing moxifloxacin 0.5% ophthalmic solution and gatifloxacin 0.3% ophthalmic solution for surgical prophylaxis in patients undergoing LASIK or LASEK. Durrie, D.S., Trattler, W. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. (2005) [Pubmed]
  5. The Zurich Study--a prospective epidemiological study of depressive, neurotic and psychosomatic syndromes. IV. Recurrent and nonrecurrent brief depression. Angst, J., Dobler-Mikola, A. European archives of psychiatry and neurological sciences. (1985) [Pubmed]
  6. Symplekin and multiple other polyadenylation factors participate in 3'-end maturation of histone mRNAs. Kolev, N.G., Steitz, J.A. Genes Dev. (2005) [Pubmed]
  7. Molecular architecture of tight junctions. Mitic, L.L., Anderson, J.M. Annu. Rev. Physiol. (1998) [Pubmed]
  8. Symplekin, a novel type of tight junction plaque protein. Keon, B.H., Schäfer, S., Kuhn, C., Grund, C., Franke, W.W. J. Cell Biol. (1996) [Pubmed]
  9. HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin. Xing, H., Mayhew, C.N., Cullen, K.E., Park-Sarge, O.K., Sarge, K.D. J. Biol. Chem. (2004) [Pubmed]
  10. Chromosomal localization to 19q13.3, partial genomic structure and 5' cDNA sequence of the human symplekin gene. Ueki, K., Ramaswamy, S., Billings, S.J., Mohrenweiser, H.W., Louis, D.N. Somat. Cell Mol. Genet. (1997) [Pubmed]
  11. Rice SPK, a calmodulin-like domain protein kinase, is required for storage product accumulation during seed development: phosphorylation of sucrose synthase is a possible factor. Asano, T., Kunieda, N., Omura, Y., Ibe, H., Kawasaki, T., Takano, M., Sato, M., Furuhashi, H., Mujin, T., Takaiwa, F., Wu Cy, C.Y., Tada, Y., Satozawa, T., Sakamoto, M., Shimada, H. Plant Cell (2002) [Pubmed]
  12. A study comparing mycophenolate mofetil to azathioprine in simultaneous pancreas-kidney transplantation. Odorico, J.S., Pirsch, J.D., Knechtle, S.J., D'Alessandro, A.M., Sollinger, H.W. Transplantation (1998) [Pubmed]
  13. The complete nucleotide sequence of tobacco rattle virus RNA-1. Hamilton, W.D., Boccara, M., Robinson, D.J., Baulcombe, D.C. J. Gen. Virol. (1987) [Pubmed]
  14. Functional interaction between the ZO-1-interacting transcription factor ZONAB/DbpA and the RNA processing factor symplekin. Kavanagh, E., Buchert, M., Tsapara, A., Choquet, A., Balda, M.S., Hollande, F., Matter, K. J. Cell. Sci. (2006) [Pubmed]
  15. (2S,4R)-4-methylglutamic acid (SYM 2081): a selective, high-affinity ligand for kainate receptors. Zhou, L.M., Gu, Z.Q., Costa, A.M., Yamada, K.A., Mansson, P.E., Giordano, T., Skolnick, P., Jones, K.A. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  16. In vitro engineering of human stratified urothelium: analysis of its morphology and function. Sugasi, S., Lesbros, Y., Bisson, I., Zhang, Y.Y., Kucera, P., Frey, P. J. Urol. (2000) [Pubmed]
  17. Influence of agonist concentration on AMPA and kainate channels in CA1 pyramidal cells in rat hippocampal slices. Gebhardt, C., Cull-Candy, S.G. J. Physiol. (Lond.) (2006) [Pubmed]
  18. A three-year experience with serum anodal trypsinogen as a biochemical marker for rejection in pancreatic allografts. False positives, tissue biopsy, comparison with other markers, and diagnostic strategies. Perkal, M., Marks, C., Lorber, M.I., Marks, W.H. Transplantation (1992) [Pubmed]
  19. Cytomegalovirus disease recurrence after ganciclovir treatment in kidney and kidney-pancreas transplant recipients. Humar, A., Uknis, M., Carlone-Jambor, C., Gruessner, R.W., Dunn, D.L., Matas, A. Transplantation (1999) [Pubmed]
  20. Randomized, prospective trial of mycophenolate mofetil versus azathioprine for prevention of acute renal allograft rejection after simultaneous kidney-pancreas transplantation. Merion, R.M., Henry, M.L., Melzer, J.S., Sollinger, H.W., Sutherland, D.E., Taylor, R.J. Transplantation (2000) [Pubmed]
  21. Pancreatic islet cells antibodies in diabetic patients submitted to pancreas transplantation. Repka, J., Nicoluzzi, J., Belila, R., Antunes, M., Caron, P. Transplant. Proc. (2006) [Pubmed]
  22. Kidney allograft outcome in simultaneous pancreas-kidney transplantation. Nakache, R., Weinbroum, A., Merhav, H., Kaplan, E., Kariv, Y., Khoury, W., Gutman, M., Klausner, J.M. Isr. Med. Assoc. J. (2000) [Pubmed]
 
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