High impact information on CSTF1

• The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression [1].
• Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50 [2].
• The BARD1-CstF-50 interaction inhibits polyadenylation in vitro [2].
• BARD1, like CstF-50, also interacts with RNA polymerase II [2].
• We therefore first identified regions of the CstF subunits, CstF-77, CstF-64, and CstF-50, required for interaction with each other [3].

Biological context of CSTF1

• In contrast, RNAi of CstF-50 in combination with RNPS1 or REFs did not result in an apparent phenotype [4].

Other interactions of CSTF1

• DeltaRIN does not interact with BRCA1, whereas it interacts with and colocalizes with CstF-50 to cytoplasmic dots [5].
• Simultaneous RNAi of SRm160 and the cleavage factor CstF-50 (Cleavage stimulation factor 50-kDa subunit) resulted in late embryonic developmental arrest [4].

Analytical, diagnostic and therapeutic context of CSTF1

• CSTF occurred after treatment times of 61-1,507 days with grouping around 324.9 +/- 148.9 days and 1,155.7 +/- 436.8 days and patients with short interinjection intervals significantly overrepresented in the first group (Mann-Whitney U test, p = 0.009) [6].

References