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Gene Review:

F2L - F2L

Variola virus

Broyles, S.S., Roseman, N.A. et al., Willer, D.O. et al.

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Disease relevance of F2L

The deoxyuridine triphosphatase gene of vaccinia virus, encoded by the open reading frame F2L, was cloned into Escherichia coli and expressed under the control of a bacteriophage T7 promoter [1].
The sequence of the vaccinia virus open reading frame F2L predicts a polypeptide with significant similarity to cellular dUTPases [2].
SFV preserves the Chordopoxvirinae gene order from S012L near the left end of the chromosome through to S142R (homologs of vaccinia F2L and B1R, respectively) [3].

High impact information on F2L

To determine whether the F2L gene product has this activity, it was expressed in bacteria as a fusion with glutathione S-transferase [2].

References

Purification and characterization of the vaccinia virus deoxyuridine triphosphatase expressed in Escherichia coli. Roseman, N.A., Evans, R.K., Mayer, E.L., Rossi, M.A., Slabaugh, M.B. J. Biol. Chem. (1996) [Pubmed]
Vaccinia virus encodes a functional dUTPase. Broyles, S.S. Virology (1993) [Pubmed]
The complete genome sequence of shope (rabbit) fibroma virus. Willer, D.O., McFadden, G., Evans, D.H. Virology (1999) [Pubmed]

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