Gene Review:
A45R - A45R
Variola virus
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Disease relevance of A45R
- A characterization of the A45R gene from vaccinia virus (VV) strain Western Reserve is presented [1].
- A monoclonal antibody raised against the A45R protein expressed in E. coli identified the A45R gene product as a 13.5-kDa protein that is expressed late during VV infection [1].
- Sequencing of the A45R gene from other orthopoxviruses, here and by others, showed that the protein is highly conserved in all viruses sequenced, including 16 strains of VV, 2 strains of cowpox virus, camelpox virus, and 4 strains of variola virus [1].
High impact information on A45R
- A45R is unusual in being the first VV core protein described that affects neither virus replication nor virulence [1].
Analytical, diagnostic and therapeutic context of A45R
- Confocal microscopy of VV-infected cells indicated that the A45R protein accumulated predominantly in cytoplasmic viral factories [1].
References
- The vaccinia virus superoxide dismutase-like protein (A45R) is a virion component that is nonessential for virus replication. Almazán, F., Tscharke, D.C., Smith, G.L. J. Virol. (2001) [Pubmed]
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