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Gene Review:

UL56 - type 2 membrane protein

Human herpesvirus 2

Koshizuka, T. et al., McGeoch, D.J. et al., Spector, F.C. et al., Koshizuka, T. et al.

Spector, Kern, Palmer, Kaiwar, Cha, Brown, Spaete,

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Disease relevance of UL56

The herpes simplex virus UL56 gene product is a C-terminal-anchored, type II membrane protein of unknown function [1].
Comparison of the HSV-1 and HSV-2 UL56 sequences led to a correction in the published HSV-1 UL56 reading frame [2].

High impact information on UL56

Recombinant virus RAV 9395 was constructed by deleting both copies of the gamma(1)34.5 gene, and the UL55 and UL56 open reading frames from herpes simplex virus type 2 (HSV-2) strain G [3].
The 4355 bp sequenced at the right end of UL contained coding regions for part of gene UL53, and the whole of genes UL54 to UL56 [2].
We show here that UL11 interacts with UL56 protein, a tail-anchored type II membrane protein encoded by HSV, which associated with the Golgi apparatus and cytoplasmic vesicles [4].

Biological context of UL56

Fatty acylation of UL11 was important for the formation of the UL11-UL56 protein complex [4].

Other interactions of UL56

The UL11-UL56 complex localized to the perinuclear region of the cytoplasm in infected cells [4].

References

Herpes simplex virus type 2 membrane protein UL56 associates with the kinesin motor protein KIF1A. Koshizuka, T., Kawaguchi, Y., Nishiyama, Y. J. Gen. Virol. (2005) [Pubmed]
Comparative sequence analysis of the long repeat regions and adjoining parts of the long unique regions in the genomes of herpes simplex viruses types 1 and 2. McGeoch, D.J., Cunningham, C., McIntyre, G., Dolan, A. J. Gen. Virol. (1991) [Pubmed]
Evaluation of a live attenuated recombinant virus RAV 9395 as a herpes simplex virus type 2 vaccine in guinea pigs. Spector, F.C., Kern, E.R., Palmer, J., Kaiwar, R., Cha, T.A., Brown, P., Spaete, R.R. J. Infect. Dis. (1998) [Pubmed]
Association of Two Membrane Proteins Encoded by Herpes Simplex Virus Type 2, UL11 and UL56. Koshizuka, T., Kawaguchi, Y., Goshima, F., Mori, I., Nishiyama, Y. Virus Genes (2006) [Pubmed]

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