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Gene Review:

DHFR - dihydrofolate reductase

Saimiriine herpesvirus 2

Biesinger, B. et al., Alexander, L. et al., Albrecht, J.C. et al.

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Disease relevance of DHFR

All homologues are correspondingly located in KSHV and RRV with the exception of dihydrofolate reductase (DHFR) [1].

High impact information on DHFR

DHFR is correspondingly located near the left end of the genome in RRV26-95 and herpesvirus saimiri (HVS), but in KSHV the DHFR gene is displaced 16,069 nucleotides in a rightward direction in the genome [1].
These include thymidylate synthase, dihydrofolate reductase, complement control proteins, the cell surface antigen CD59, cyclins, and G protein-coupled receptors [2].
Furthermore, this same region contains an open reading frame (ORF) for dihydrofolate reductase (DHFR) and genes for five virus-specific U RNAs (HSURs) [3].
We now show by sequence analysis of the corresponding region in a subgroup C strain that DHFR and HSUR genes are present in both virus subgroups; however, no sequence homologous to the STP-A reading frame was found in this subgroup C virus [3].

References

The primary sequence of rhesus monkey rhadinovirus isolate 26-95: sequence similarities to Kaposi's sarcoma-associated herpesvirus and rhesus monkey rhadinovirus isolate 17577. Alexander, L., Denekamp, L., Knapp, A., Auerbach, M.R., Damania, B., Desrosiers, R.C. J. Virol. (2000) [Pubmed]
Primary structure of the herpesvirus saimiri genome. Albrecht, J.C., Nicholas, J., Biller, D., Cameron, K.R., Biesinger, B., Newman, C., Wittmann, S., Craxton, M.A., Coleman, H., Fleckenstein, B. J. Virol. (1992) [Pubmed]
The divergence between two oncogenic Herpesvirus saimiri strains in a genomic region related to the transforming phenotype. Biesinger, B., Trimble, J.J., Desrosiers, R.C., Fleckenstein, B. Virology (1990) [Pubmed]

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