Disease relevance of Herpesvirus 2, Saimiriine

• One of these factors, AK155 or IL-26, was discovered because of its overexpression in human T lymphocytes after growth transformation by the simian rhadinovirus herpesvirus saimiri [1].
• ORF73 of herpesvirus saimiri, a viral homolog of Kaposi's sarcoma-associated herpesvirus, modulates the two cellular tumor suppressor proteins p53 and pRb [2].
• The improtance of hydrophobic residues was further substantiated by comparing EBV Rta with that of herpesvirus saimiri, which revealed little sequence similarity except for a few acidic residues and the positionally conserved hydrophobic amino acids [3].
• Our previous studies have demonstrated that Tip of herpesvirus saimiri (HVS), which is a T-lymphotropic tumor virus, is constitutively targeted to lipid rafts and interacts with cellular Lck tyrosine kinase and p80 WD repeat-containing endosomal protein [4].
• The antiviral effects of four compounds, phosphonoacetate, phosphonoformate, acycloguanosine, and purified human lymphoblastic interferon, were tested against two neurotropic herpesviruses, herpesvirus platyrrhine and herpes simplex virus, and two oncogenic herpesviruses, herpesvirus saimiri and herpesvirus ateles [5].

High impact information on Herpesvirus 2, Saimiriine

• The herpesvirus saimiri FLIP is detected late during the lytic viral replication cycle, at a time when host cells are partially protected from CD95-ligand-mediated apoptosis [6].
• Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins [7].
• The herpesvirus saimiri DHFR gene is devoid of intron sequences, suggesting that it was acquired by some process involving reverse transcription [8].
• The predicted sequence of herpesvirus saimiri DHFR is 186 amino acids in length, the same length as human, murine, and bovine DHFR [8].
• Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor [9].

Chemical compound and disease context of Herpesvirus 2, Saimiriine

• The tyrosine kinase-interacting protein (Tip) of the T lymphotropic Herpesvirus saimiri (HVS) is constitutively present in lipid rafts and interacts with cellular Lck tyrosine kinase and p80 endosomal protein [10].
• Effect of bacillus Calmette-Guérin immunization in marmosets infected experimentally with Herpesvirus saimiri [11].
• Inhibition of Herpesvirus saimiri replication by phosphonoacetic acid, benzo(a)pyrene, and methylcholanthrene [12].
• We have reported previously the detection of two stable immediate-early (IE) transcripts that accumulate in cycloheximide-treated cells infected with herpesvirus saimiri (HVS) [13].
• The complement control protein homolog of herpesvirus saimiri regulates serum complement by inhibiting C3 convertase activity [14].

Biological context of Herpesvirus 2, Saimiriine

• The product of the Herpesvirus saimiri open reading frame 1 (tip) interacts with T cell-specific kinase p56lck in transformed cells [15].
• Activation of the lck tyrosine-protein kinase by the binding of the tip protein of herpesvirus saimiri in the absence of regulatory tyrosine phosphorylation [16].
• CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene [17].
• The encoded viral protein, termed Tio, shows restricted homology to the oncoprotein StpC and to the tyrosine kinase-interacting protein Tip, two gene products responsible for the T-cell-transforming and oncogenic phenotype of herpesvirus saimiri group C strains [18].
• Downregulation of p56(lck) tyrosine kinase activity in T cells of squirrel monkeys (Saimiri sciureus) correlates with the nontransforming and apathogenic properties of herpesvirus saimiri in its natural host [19].

Anatomical context of Herpesvirus 2, Saimiriine

• Transformation of human T-cell clones by Herpesvirus saimiri: intact antigen recognition by autonomously growing myelin basic protein-specific T cells [20].

Gene context of Herpesvirus 2, Saimiriine

• Cyclin from herpesvirus saimiri (Vcyclin) preferentially forms complexes with cyclin-dependent kinase 6 (CDK6) from primate host cells [21].
• Molecular piracy of mammalian interleukin-8 receptor type B by herpesvirus saimiri [22].
• T-cell growth transformation by herpesvirus saimiri is independent of STAT3 activation [23].
• Activation of STAT transcription factors by herpesvirus Saimiri Tip-484 requires p56lck [24].
• Activation of Stat3 transcription factor by Herpesvirus saimiri STP-A oncoprotein [25].

Analytical, diagnostic and therapeutic context of Herpesvirus 2, Saimiriine

• Using cDNA arrays and suppressive subtractive hybridization, we were able to identify the chemokine CCL1/I-309 as one of the few cellular genes that are strongly overexpressed in T cells after growth transformation with herpesvirus saimiri [26].
• Immunosuppression of juvenile squirrel monkeys with combined azathioprine, prednisolone, and antilymphocyte globulin resulted in decreased antibody responses to viral antigens after primary infection with Herpesvirus saimiri (HVS) [27].

References