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MeSH Review

Herpesvirus 8, Human

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Disease relevance of Herpesvirus 8, Human


High impact information on Herpesvirus 8, Human

  • HHV-8 envelope glycoprotein B possesses the RGD motif known to interact with integrin molecules, and HHV-8 infectivity was inhibited by RGD peptides, antibodies against RGD-dependent alpha3 and beta1 integrins, and by soluble alpha3beta1 integrin [6].
  • These findings implicate a role for alpha3beta1 integrin and the associated signaling pathways in HHV-8 entry into the target cells [6].
  • Further, HHV-8 infection induced the integrin-mediated activation of focal adhesion kinase (FAK) [6].
  • Identification of the highly variable K1 gene sequence of the HHV-8 genome in both the donor's peripheral-blood cells and the recipients' serum confirmed that transmission had occurred [7].
  • A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency [8].

Chemical compound and disease context of Herpesvirus 8, Human


Biological context of Herpesvirus 8, Human


Anatomical context of Herpesvirus 8, Human

  • We show that the HHV-8-encoded IL-6 homologue (vIL-6) shares functional properties with endogenous IL-6 proteins and that both vIL-6 and vMIP-1 transcripts are present at high levels following butyrate induction of an HHV-8' BCBL cell line [19].
  • We have examined the susceptibility of C.B-17 scid/scid mice implanted with human fetal thymus and liver grafts (SCID-hu Thy/Liv mice) to KSHV infection [20].
  • The human herpesvirus 8 chemokine receptor vGPCR triggers autonomous proliferation of endothelial cells [2].
  • FINDINGS: HHV-8 ORF 26 DNA was detected in significantly higher proportions of sarcoid than of non-sarcoid tissue samples from lung (8/8 vs 0/54; p < 0.0001), lymph nodes (26/27 vs 6/29; p < 0.0001), skin (2/2 vs 0/17; p = 0.006), and oral tissues (2/2 vs 1/13; p = 0.029) [21].
  • In addition, HHV-8 colocalizes with vascular endothelial growth factor receptor-3 (VEGFR-3), a marker of lymphatic and precursor endothelium [22].

Gene context of Herpesvirus 8, Human

  • Therefore, manipulation of the stability and function of IRF7 by the KSHV RTA transcription factor provides an unexpected regulatory strategy for circumventing the innate immune defence system [23].
  • Cyclin D family members are cellular protooncogenes, and their viral homologues in the Kaposi's sarcoma-associated herpesvirus (KSHV, human herpesvirus type 8 [HHV-8]) and the closely related Herpesvirus saimiri have been implicated as putative cofactors of viral transformation and pathogenesis [24].
  • Our results demonstrate for the first time, to our knowledge, that KSHV vFLIP K13 is required for the growth and proliferation of PEL cells and alternative NF-kappa B pathway plays a key role in this process [25].
  • These findings suggest that KSHV may promote oncogenesis in PEL by expressing v-cyclin, which both overrides negative cell cycle controls present in the PEL precursor cells and induces a strong proliferative signal via CDK6 kinase activity [26].
  • Transcriptional activation of nuclear factor-kappaB, as induced by the KS-promoting factor TNF-alpha, the HIV-1 Tat protein, or the human herpesvirus 8 protein ORF74, was inhibited by ritonavir [27].

Analytical, diagnostic and therapeutic context of Herpesvirus 8, Human


  1. Deregulation of cell growth by the K1 gene of Kaposi's sarcoma-associated herpesvirus. Lee, H., Veazey, R., Williams, K., Li, M., Guo, J., Neipel, F., Fleckenstein, B., Lackner, A., Desrosiers, R.C., Jung, J.U. Nat. Med. (1998) [Pubmed]
  2. The human herpesvirus 8 chemokine receptor vGPCR triggers autonomous proliferation of endothelial cells. Grisotto, M.G., Garin, A., Martin, A.P., Jensen, K.K., Chan, P., Sealfon, S.C., Lira, S.A. J. Clin. Invest. (2006) [Pubmed]
  3. Mitochondria as functional targets of proteins coded by human tumor viruses. D'Agostino, D.M., Bernardi, P., Chieco-Bianchi, L., Ciminale, V. Adv. Cancer Res. (2005) [Pubmed]
  4. The targeting of primary effusion lymphoma cells for apoptosis by inducing lytic replication of human herpesvirus 8 while blocking virus production. Klass, C.M., Krug, L.T., Pozharskaya, V.P., Offermann, M.K. Blood (2005) [Pubmed]
  5. Long-term remission of Kaposi sarcoma-associated herpesvirus-related multicentric Castleman disease with anti-CD20 monoclonal antibody therapy. Corbellino, M., Bestetti, G., Scalamogna, C., Calattini, S., Galazzi, M., Meroni, L., Manganaro, D., Fasan, M., Moroni, M., Galli, M., Parravicini, C. Blood (2001) [Pubmed]
  6. Integrin alpha3beta1 (CD 49c/29) is a cellular receptor for Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) entry into the target cells. Akula, S.M., Pramod, N.P., Wang, F.Z., Chandran, B. Cell (2002) [Pubmed]
  7. Bone marrow failure associated with human herpesvirus 8 infection after transplantation. Luppi, M., Barozzi, P., Schulz, T.F., Setti, G., Staskus, K., Trovato, R., Narni, F., Donelli, A., Maiorana, A., Marasca, R., Sandrini, S., Torelli, G. N. Engl. J. Med. (2000) [Pubmed]
  8. A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency. Fujimuro, M., Wu, F.Y., ApRhys, C., Kajumbula, H., Young, D.B., Hayward, G.S., Hayward, S.D. Nat. Med. (2003) [Pubmed]
  9. Signaling by human herpesvirus 8 kaposin A through direct membrane recruitment of cytohesin-1. Kliche, S., Nagel, W., Kremmer, E., Atzler, C., Ege, A., Knorr, T., Koszinowski, U., Kolanus, W., Haas, J. Mol. Cell (2001) [Pubmed]
  10. Kaposi's sarcoma (KS)-associated herpesvirus-like DNA sequences in peripheral blood mononuclear cells: association with KS and persistence in patients receiving anti-herpesvirus drugs. Humphrey, R.W., O'Brien, T.R., Newcomb, F.M., Nishihara, H., Wyvill, K.M., Ramos, G.A., Saville, M.W., Goedert, J.J., Straus, S.E., Yarchoan, R. Blood (1996) [Pubmed]
  11. Cidofovir on HHV-8 in BCBL-1 cells. Pica, F., Serafino, A., Garaci, E., Volpi, A. Antivir. Ther. (Lond.) (2004) [Pubmed]
  12. Identification of an immunoreceptor tyrosine-based activation motif of K1 transforming protein of Kaposi's sarcoma-associated herpesvirus. Lee, H., Guo, J., Li, M., Choi, J.K., DeMaria, M., Rosenzweig, M., Jung, J.U. Mol. Cell. Biol. (1998) [Pubmed]
  13. Remission of HHV-8 and HIV-associated multicentric Castleman disease with ganciclovir treatment. Casper, C., Nichols, W.G., Huang, M.L., Corey, L., Wald, A. Blood (2004) [Pubmed]
  14. G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Bais, C., Santomasso, B., Coso, O., Arvanitakis, L., Raaka, E.G., Gutkind, J.S., Asch, A.S., Cesarman, E., Gershengorn, M.C., Mesri, E.A., Gerhengorn, M.C. Nature (1998) [Pubmed]
  15. p53 inhibition by the LANA protein of KSHV protects against cell death. Friborg, J., Kong, W., Hottiger, M.O., Nabel, G.J. Nature (1999) [Pubmed]
  16. The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway. Liang, Y., Chang, J., Lynch, S.J., Lukac, D.M., Ganem, D. Genes Dev. (2002) [Pubmed]
  17. A secreted chemokine binding protein encoded by murine gammaherpesvirus-68 is necessary for the establishment of a normal latent load. Bridgeman, A., Stevenson, P.G., Simas, J.P., Efstathiou, S. J. Exp. Med. (2001) [Pubmed]
  18. Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus. Lagunoff, M., Majeti, R., Weiss, A., Ganem, D. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  19. Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6. Nicholas, J., Ruvolo, V.R., Burns, W.H., Sandford, G., Wan, X., Ciufo, D., Hendrickson, S.B., Guo, H.G., Hayward, G.S., Reitz, M.S. Nat. Med. (1997) [Pubmed]
  20. Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SCID-hu Thy/Liv mice. Dittmer, D., Stoddart, C., Renne, R., Linquist-Stepps, V., Moreno, M.E., Bare, C., McCune, J.M., Ganem, D. J. Exp. Med. (1999) [Pubmed]
  21. Human herpesvirus 8 variants in sarcoid tissues. Di Alberti, L., Piattelli, A., Artese, L., Favia, G., Patel, S., Saunders, N., Porter, S.R., Scully, C.M., Ngui, S.L., Teo, C.G. Lancet (1997) [Pubmed]
  22. Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma. Dupin, N., Fisher, C., Kellam, P., Ariad, S., Tulliez, M., Franck, N., van Marck, E., Salmon, D., Gorin, I., Escande, J.P., Weiss, R.A., Alitalo, K., Boshoff, C. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  23. The KSHV immediate-early transcription factor RTA encodes ubiquitin E3 ligase activity that targets IRF7 for proteosome-mediated degradation. Yu, Y., Wang, S.E., Hayward, G.S. Immunity (2005) [Pubmed]
  24. Independence of herpesvirus-induced T cell lymphoma from viral cyclin D homologue. Ensser, A., Glykofrydes, D., Niphuis, H., Kuhn, E.M., Rosenwirth, B., Heeney, J.L., Niedobitek, G., Müller-Fleckenstein, I., Fleckenstein, B. J. Exp. Med. (2001) [Pubmed]
  25. Activation of alternative NF-kappa B pathway by human herpes virus 8-encoded Fas-associated death domain-like IL-1 beta-converting enzyme inhibitory protein (vFLIP). Matta, H., Chaudhary, P.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  26. KSHV viral cyclin binds to p27KIP1 in primary effusion lymphomas. Järviluoma, A., Koopal, S., Räsänen, S., Mäkelä, T.P., Ojala, P.M. Blood (2004) [Pubmed]
  27. Antitumorigenic effects of HIV protease inhibitor ritonavir: inhibition of Kaposi sarcoma. Pati, S., Pelser, C.B., Dufraine, J., Bryant, J.L., Reitz, M.S., Weichold, F.F. Blood (2002) [Pubmed]
  28. Detection and titration of human herpesvirus-8-specific antibodies in sera from blood donors, acquired immunodeficiency syndrome patients, and Kaposi's sarcoma patients using a whole virus enzyme-linked immunosorbent assay. Chatlynne, L.G., Lapps, W., Handy, M., Huang, Y.Q., Masood, R., Hamilton, A.S., Said, J.W., Koeffler, H.P., Kaplan, M.H., Friedman-Kien, A., Gill, P.S., Whitman, J.E., Ablashi, D.V. Blood (1998) [Pubmed]
  29. Molecular and serological examination of the relationship of human herpesvirus 8 to multiple myeloma: orf 26 sequences in bone marrow stroma are not restricted to myeloma patients and other regions of the genome are not detected. Tisdale, J.F., Stewart, A.K., Dickstein, B., Little, R.F., Dubé, I., Cappe, D., Dunbar, C.E., Brown, K.E. Blood (1998) [Pubmed]
  30. Risk of Kaposi's sarcoma-associated herpes virus transmission from donor allografts among Italian posttransplant Kaposi's sarcoma patients. Parravicini, C., Olsen, S.J., Capra, M., Poli, F., Sirchia, G., Gao, S.J., Berti, E., Nocera, A., Rossi, E., Bestetti, G., Pizzuto, M., Galli, M., Moroni, M., Moore, P.S., Corbellino, M. Blood (1997) [Pubmed]
  31. High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric castleman disease in HIV-infected patients. Oksenhendler, E., Carcelain, G., Aoki, Y., Boulanger, E., Maillard, A., Clauvel, J.P., Agbalika, F. Blood (2000) [Pubmed]
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