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Gene Review

HpVgp5  -  capsid protein

Hamster polyomavirus

 
 
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Disease relevance of HpVgp5

 

High impact information on HpVgp5

  • The sequence information needed for assigning genotypes can be captured by VP1, VP2, VP3, or large T-gene sequencing [4].
  • VP2 and VP3, but not VP1, caused the permeabilization of bacterial membranes [5].
  • These constructs were transfected into COS-7 cells, and the intracellular localization of the VP2 protein was determined by indirect immunofluorescence [6].
  • To avoid false positive results, due to contamination with commonly used SV40 T-antigen plasmids, a conserved region of the VP2 gene was targeted [7].
 

Analytical, diagnostic and therapeutic context of HpVgp5

  • The major VP-2 protein could be resolved in the form of a consistent pattern of three abundant (a to c), two intermediate (d and e), and one meager (f) neutral isoelectric focusing species or subtypes [8].

References

  1. 19S late mRNAs of simian virus 40 have an internal ribosome entry site upstream of the virion structural protein 3 coding sequence. Yu, Y., Alwine, J.C. J. Virol. (2006) [Pubmed]
  2. Development of intranuclear inclusions of human polyomavirus JC. Shishido-Hara, Y. Uirusu. Journal of virology. (2006) [Pubmed]
  3. Expression and purification of recombinant polyomavirus VP2 protein and its interactions with polyomavirus proteins. Cai, X., Chang, D., Rottinghaus, S., Consigli, R.A. J. Virol. (1994) [Pubmed]
  4. Phylogenetic analysis of polyomavirus BK sequences. Sharma, P.M., Gupta, G., Vats, A., Shapiro, R., Randhawa, P. J. Virol. (2006) [Pubmed]
  5. Simian virus 40 late proteins possess lytic properties that render them capable of permeabilizing cellular membranes. Daniels, R., Rusan, N.M., Wilbuer, A.K., Norkin, L.C., Wadsworth, P., Hebert, D.N. J. Virol. (2006) [Pubmed]
  6. Identification of a nuclear localization sequence in the polyomavirus capsid protein VP2. Chang, D., Haynes, J.I., Brady, J.N., Consigli, R.A. Virology (1992) [Pubmed]
  7. Quantitative real-time PCR assay for detection of human polyomavirus infection. Elfaitouri, A., Hammarin, A.L., Blomberg, J. J. Virol. Methods (2006) [Pubmed]
  8. Protein species of the parvovirus minute virus of mice strain MVMp: involvement of phosphorylated VP-2 subtypes in viral morphogenesis. Santarén, J.F., Ramírez, J.C., Almendral, J.M. J. Virol. (1993) [Pubmed]
 
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