Disease relevance of HpVgp5

• The 19S mRNAs encode primarily the virion structural proteins VP2 and VP3 [1].
• The outer capsid of JCV is thought to be composed of 360 molecules of major capsid protein VP1, and minor capsid proteins VP2 and VP3 in an appropriate ratio [2].
• Expression and purification of recombinant polyomavirus VP2 protein and its interactions with polyomavirus proteins [3].

High impact information on HpVgp5

• The sequence information needed for assigning genotypes can be captured by VP1, VP2, VP3, or large T-gene sequencing [4].
• VP2 and VP3, but not VP1, caused the permeabilization of bacterial membranes [5].
• These constructs were transfected into COS-7 cells, and the intracellular localization of the VP2 protein was determined by indirect immunofluorescence [6].
• To avoid false positive results, due to contamination with commonly used SV40 T-antigen plasmids, a conserved region of the VP2 gene was targeted [7].

Analytical, diagnostic and therapeutic context of HpVgp5

• The major VP-2 protein could be resolved in the form of a consistent pattern of three abundant (a to c), two intermediate (d and e), and one meager (f) neutral isoelectric focusing species or subtypes [8].

References