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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

E6  -  E6 protein

Alphapapillomavirus 7

 
 
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Disease relevance of E6

 

High impact information on E6

  • Human T cell leukemia virus type 1 Tax and most oncogenic human papillomavirus E6 oncoproteins also possessed PDZ domain-binding motifs at their C termini and, significantly, human T cell leukemia virus type 1 Tax and human papillomavirus 18 E6 proteins bound DLG in vitro [2].
  • Conversely, silencing of E6 increases the expression of Id3 and blocks proliferation of HeLa cells [3].
 

Biological context of E6

  • Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome. Phylogeny of papillomaviruses and repeated structure of the E6 and E7 gene products [4].
  • Viral gene products known to be involved in cellular transformation are those of ORFs E5, E6 and E7 [4].

References

  1. Silencing of integrated human papillomavirus type 18 oncogene transcription in cells expressing SerpinB2. Darnell, G.A., Antalis, T.M., Rose, B.R., Suhrbier, A. J. Virol. (2005) [Pubmed]
  2. Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein. Lee, S.S., Weiss, R.S., Javier, R.T. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  3. Human papillomavirus type 18 E6 protein binds the cellular PDZ protein TIP-2/GIPC, which is involved in transforming growth factor beta signaling and triggers its degradation by the proteasome. Favre-Bonvin, A., Reynaud, C., Kretz-Remy, C., Jalinot, P. J. Virol. (2005) [Pubmed]
  4. Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome. Phylogeny of papillomaviruses and repeated structure of the E6 and E7 gene products. Cole, S.T., Danos, O. J. Mol. Biol. (1987) [Pubmed]
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