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Gene Review:

vif - vif protein

Visna/maedi virus

Kristbjörnsdóttir, H.B. et al., Hötzel, I. et al.

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Disease relevance of vif

Replication-defective CAEV proviral constructs lacking the env, tat, and vif genes and carrying the neomycin phosphotransferase gene in the vif-tat region were developed for the infectivity assays [1].
The vif gene of maedi-visna virus is essential for infectivity in vivo and in vitro [2].

High impact information on vif

By measuring RT activity, we found that in comparison to wild-type MVV, growth of vif-deleted MVV was similar in fetal ovine synovial (FOS) cells, highly attenuated in sheep choroid plexus (SCP) cells, and not detectable in macrophages, natural target cells of MVV [2].
These results suggest that the vif gene of MVV is essential for infectivity and that the Vif protein protects the viral genome from enpackaged mutagenic activities [2].

References

Host range of small-ruminant lentivirus cytopathic variants determined with a selectable caprine arthritis- encephalitis virus pseudotype system. Hötzel, I., Cheevers, W.P. J. Virol. (2001) [Pubmed]
The vif gene of maedi-visna virus is essential for infectivity in vivo and in vitro. Kristbjörnsdóttir, H.B., Andrésdóttir, V., Svansson, V., Torsteinsdóttir, S., Matthíasdóttir, S., Andrésson, O.S. Virology (2004) [Pubmed]

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