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Chemical Compound Review

AC1L9ZFX     (2S,3S,4R,5R,6R)-5-amino-6- [(2R,3S,4R,5R)...

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Disease relevance of neomycin


Psychiatry related information on neomycin

  • Spontaneous intake of neomycin for 7 days at doses comparable to human usage (0.1 to 0.2 gm/kg/day) was associated with a significant increase in spontaneous motor activity in rats subjected to portacaval shunt (26.4% in group A, 66.3% in group B; p < 0.01 for each protocol) with no significant effect in sham-operated animals [6].
  • Results of experimental treatments with neomycin at various times during the incubation with PDGF indicate that the critical period during which PDGF acts to stimulate DNA synthesis is after the 1st h but before the 12th h of incubation [7].
  • Moreover auditory brainstem testing revealed no change in auditory thresholds in the ofloxacin-treated animals, whereas neomycin-treated animals showed substantial threshold shifts [8].
  • The presence of micromolar concentrations of neomycin in the cell medium causes both prolongation of response latency and decrease of cell photoresponsiveness [9].

High impact information on neomycin

  • The beta-amyloid precursor protein (beta APP) gene of the mouse was disrupted by inserting into exon 2 a cassette containing a neomycin resistance gene and a putative transcription termination sequence [10].
  • We replaced the IgH 3' enhancer (3'EH) region with a neomycin resistance gene in ES cells and generated chimeric mice in which all mature lymphocytes were either heterozygous (3'EH+/-) or homozygous (3'EH-/-) for the mutation [11].
  • We further demonstrate that neomycin B can specifically antagonize Rev function in vitro and in vivo and can inhibit production of HIV [1].
  • We have marked a cloned mouse IAP sequence with a neomycin-containing indicator gene whose expression is conditioned by passage of the transposon through an RNA intermediate [12].
  • The presence and expression of the neomycin-resistance gene were demonstrated in TIL from all the patients with Southern blot analysis and enzymatic assay for the neomycin phosphotransferase coded by the bacterial gene [13].

Chemical compound and disease context of neomycin


Biological context of neomycin


Anatomical context of neomycin

  • Stable myogenic cell lines have been derived at a high frequency by transfection of a cloned multipotential mouse embryo cell line, C3H 10T1/2, with cloned human DNA linked to a selectable neomycin resistance gene [19].
  • Cells from four of the five patients grew successfully in high concentrations of G418, a neomycin analogue otherwise toxic to eukaryotic cells [13].
  • Bone marrow cells infected with retroviral vectors carrying the bacterial neomycin resistance (neo) gene as a marker were used for long-term reconstitution of the haematopoietic system of irradiated mice [24].
  • To study T-cell survival, we adoptively transferred peripheral blood lymphocytes transduced with the neomycin phosphotransferase gene between syngeneic twin pairs discordant for HIV infection [25].
  • We now provide evidence that mast cell secretion is inhibited by internalized neomycin, a compound known to interact with PPI [26].

Associations of neomycin with other chemical compounds


Gene context of neomycin

  • Two cell clones expressed high levels of cyclin D1 mRNA and protein as compared with control cells transfected with plasmids containing the neomycin-resistance gene only [31].
  • The genomic sequences comprising exon 2 through 5 of the u-PAR gene were replaced by the neomycin resistance gene, resulting in inactivation of both u-PAR splice variants [32].
  • Surprisingly, however, neither PLD nor neomycin has any effect on the recruitment of AP-1 adaptors onto the TGN, even though AP-1 recruitment is ARF mediated [33].
  • We then generated ezrin knockdown (Vil2(kd/kd)) mice by introducing a neomycin resistance cassette between exons 2 and 3 [34].
  • To investigate the role of HLF in adult pathological angiogenesis, we generated HLF-knockdown (HLF(kd/kd)) mice by inserting a neomycin gene sandwiched between two loxP sequences into exon 1 of the HLF gene [35].

Analytical, diagnostic and therapeutic context of neomycin


  1. Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production. Zapp, M.L., Stern, S., Green, M.R. Cell (1993) [Pubmed]
  2. Regeneration of intact tobacco plants containing full length copies of genetically engineered T-DNA, and transmission of T-DNA to R1 progeny. Barton, K.A., Binns, A.N., Matzke, A.J., Chilton, M.D. Cell (1983) [Pubmed]
  3. Neomycin for hypercholesterolemia. Meisel, S., Rate, R. N. Engl. J. Med. (1980) [Pubmed]
  4. Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse. Williams, D.A., Lemischka, I.R., Nathan, D.G., Mulligan, R.C. Nature (1984) [Pubmed]
  5. Design of liposomes for enhanced local release of drugs by hyperthermia. Yatvin, M.B., Weinstein, J.N., Dennis, W.H., Blumenthal, R. Science (1978) [Pubmed]
  6. Reversal of behavioral changes in rats subjected to portacaval shunt with oral neomycin therapy. Conjeevaram, H.S., Nagle, A., Katz, A., Kaminsky-Russ, K., McCullough, A.J., Mullen, K.D. Hepatology (1994) [Pubmed]
  7. The effect of neomycin on PDGF-induced mitogenic response and actin organization in cultured human fibroblasts. Hedberg, K.M., Bell, P.B. Exp. Cell Res. (1995) [Pubmed]
  8. Safety of ofloxacin otic and other ototopical treatments in animal models and in humans. Gates, G.A. Pediatr. Infect. Dis. J. (2001) [Pubmed]
  9. Contribution of phosphoinositide-dependent signalling to photomotility of Blepharisma ciliate. Fabczak, H. J. Photochem. Photobiol. B, Biol. (2000) [Pubmed]
  10. Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene. Müller, U., Cristina, N., Li, Z.W., Wolfer, D.P., Lipp, H.P., Rülicke, T., Brandner, S., Aguzzi, A., Weissmann, C. Cell (1994) [Pubmed]
  11. A class switch control region at the 3' end of the immunoglobulin heavy chain locus. Cogné, M., Lansford, R., Bottaro, A., Zhang, J., Gorman, J., Young, F., Cheng, H.L., Alt, F.W. Cell (1994) [Pubmed]
  12. Retrotransposition of a mouse IAP sequence tagged with an indicator gene. Heidmann, O., Heidmann, T. Cell (1991) [Pubmed]
  13. Gene transfer into humans--immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction. Rosenberg, S.A., Aebersold, P., Cornetta, K., Kasid, A., Morgan, R.A., Moen, R., Karson, E.M., Lotze, M.T., Yang, J.C., Topalian, S.L. N. Engl. J. Med. (1990) [Pubmed]
  14. Footprinting the sites of interaction of antibiotics with catalytic group I intron RNA. von Ahsen, U., Noller, H.F. Science (1993) [Pubmed]
  15. Contact dermatitis to neomycin sulfate. Leyden, J.J., Kligman, A.M. JAMA (1979) [Pubmed]
  16. Rapid emergence of El Tor Vibrio cholerae resistant to antimicrobial agents during first six months of fourth cholera epidemic in Tanzania. Mhalu, F.S., Mmari, P.W., Ijumba, J. Lancet (1979) [Pubmed]
  17. Overt hepatic encephalopathy precipitated by zinc deficiency. Van der Rijt, C.C., Schalm, S.W., Schat, H., Foeken, K., De Jong, G. Gastroenterology (1991) [Pubmed]
  18. Lactose enemas plus placebo tablets vs. neomycin tablets plus starch enemas in acute portal systemic encephalopathy. A double-blind randomized controlled study. Uribe, M., Berthier, J.M., Lewis, H., Mata, J.M., Sierra, J.G., García-Ramos, G., Ramírez Acosta, J., Dehesa, M. Gastroenterology (1981) [Pubmed]
  19. Myogenic lineage determination and differentiation: evidence for a regulatory gene pathway. Pinney, D.F., Pearson-White, S.H., Konieczny, S.F., Latham, K.E., Emerson, C.P. Cell (1988) [Pubmed]
  20. The inverted repeats of Tn5 are functionally different. Rothstein, S.J., Jorgensen, R.A., Postle, K., Reznikoff, W.S. Cell (1980) [Pubmed]
  21. Reactivation of thyroglobulin gene expression in transformed thyroid cells by 5-azacytidine. Avvedimento, E.V., Obici, S., Sanchez, M., Gallo, A., Musti, A., Gottesman, M.E. Cell (1989) [Pubmed]
  22. Phosphoinositides in mitogenesis: neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation. Carney, D.H., Scott, D.L., Gordon, E.A., LaBelle, E.F. Cell (1985) [Pubmed]
  23. Targeted insertion of the neomycin phosphotransferase gene into the tubulin gene cluster of Trypanosoma brucei. ten Asbroek, A.L., Ouellette, M., Borst, P. Nature (1990) [Pubmed]
  24. Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors. Keller, G., Paige, C., Gilboa, E., Wagner, E.F. Nature (1985) [Pubmed]
  25. Peripheral expansion of pre-existing mature T cells is an important means of CD4+ T-cell regeneration HIV-infected adults. Walker, R.E., Carter, C.S., Muul, L., Natarajan, V., Herpin, B.R., Leitman, S.F., Klein, H.G., Mullen, C.A., Metcalf, J.A., Baseler, M., Falloon, J., Davey, R.T., Kovacs, J.A., Polis, M.A., Masur, H., Blaese, R.M., Lane, H.C. Nat. Med. (1998) [Pubmed]
  26. Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase. Cockcroft, S., Gomperts, B.D. Nature (1985) [Pubmed]
  27. Retrovirus-mediated transfer and expression of drug resistance genes in human haematopoietic progenitor cells. Hock, R.A., Miller, A.D. Nature (1986) [Pubmed]
  28. Reverse Translocation of tRNA in the Ribosome. Shoji, S., Walker, S.E., Fredrick, K. Mol. Cell (2006) [Pubmed]
  29. Effect of neomycin on azoxymethane-induced colon carcinogenesis in F344 rats. Reddy, B.S., Furuya, K., Lowenfels, A. J. Natl. Cancer Inst. (1984) [Pubmed]
  30. Inhibition of digoxin absorption by neomycin. Lindenbaum, J., Maulitz, R.M., Butler, V.P. Gastroenterology (1976) [Pubmed]
  31. Effect of cyclin D1 overexpression on drug sensitivity in a human fibrosarcoma cell line. Hochhauser, D., Schnieders, B., Ercikan-Abali, E., Gorlick, R., Muise-Helmericks, R., Li, W.W., Fan, J., Banerjee, D., Bertino, J.R. J. Natl. Cancer Inst. (1996) [Pubmed]
  32. Generation and characterization of urokinase receptor-deficient mice. Dewerchin, M., Nuffelen, A.V., Wallays, G., Bouché, A., Moons, L., Carmeliet, P., Mulligan, R.C., Collen, D. J. Clin. Invest. (1996) [Pubmed]
  33. The role of ADP-ribosylation factor and phospholipase D in adaptor recruitment. West, M.A., Bright, N.A., Robinson, M.S. J. Cell Biol. (1997) [Pubmed]
  34. Achlorhydria by ezrin knockdown: defects in the formation/expansion of apical canaliculi in gastric parietal cells. Tamura, A., Kikuchi, S., Hata, M., Katsuno, T., Matsui, T., Hayashi, H., Suzuki, Y., Noda, T., Tsukita, S., Tsukita, S. J. Cell Biol. (2005) [Pubmed]
  35. HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin. Morita, M., Ohneda, O., Yamashita, T., Takahashi, S., Suzuki, N., Nakajima, O., Kawauchi, S., Ema, M., Shibahara, S., Udono, T., Tomita, K., Tamai, M., Sogawa, K., Yamamoto, M., Fujii-Kuriyama, Y. EMBO J. (2003) [Pubmed]
  36. Possible role of calponin h1 as a tumor suppressor in human uterine leiomyosarcoma. Horiuchi, A., Nikaido, T., Taniguchi, S., Fujii, S. J. Natl. Cancer Inst. (1999) [Pubmed]
  37. Gene marking to determine whether autologous marrow infusion restores long-term haemopoiesis in cancer patients. Brenner, M.K., Rill, D.R., Holladay, M.S., Heslop, H.E., Moen, R.C., Buschle, M., Krance, R.A., Santana, V.M., Anderson, W.F., Ihle, J.N. Lancet (1993) [Pubmed]
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