The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Cucumovirus


High impact information on Cucumovirus


Chemical compound and disease context of Cucumovirus

  • Sequences at the 5' and 3' ends are homologous with those of the satellite of the related cucumber mosaic virus, and the double-stranded forms of both satellites contain an unpaired guanosine at the 3' end of the minus strand [11].
  • The accumulation of PR-p16.5a, PR-p16.5b, and PR-p16.5c also seems to be induced by cucumber mosaic virus and by two forms of abiotic stress, salicylic acid and ultraviolet, suggesting a general defense role for these proteins [12].
  • The N-terminal basic arm of cucumber mosaic cucumovirus (CMV) coat protein (CP) contains a conserved arginine-rich motif, which is characteristic of RNA binding proteins of several plant and nonplant viruses [13].
  • Side chains of cys64 and cys106 form the first disulfide observed in a cucumovirus, including a unique cysteine, 106, in a region otherwise conserved [14].
  • The double-stranded forms of CARNA 5 and PARNA 5, viral satellites of the cucumovirus group, after denaturation and polyacrylamide gel electrophoresis under appropriate conditions allow their complementary strands to be separated and fractionated [15].

Biological context of Cucumovirus


Anatomical context of Cucumovirus


Gene context of Cucumovirus

  • Cucumber mosaic virus 2a polymerase and 3a movement proteins independently affect both virus movement and the timing of symptom development in zucchini squash [22].
  • The capsid protein (CP) of Cucumber mosaic virus (CMV) is required for cell-to-cell movement, mediated by the 3a movement protein (MP) [23].
  • We found that NHL10 behaves like the tobacco HIN1 gene in that its transcripts are abundant in senescing leaves and they specifically accumulate during the hypersensitive response (HR) caused by exposure to an avirulent Cucumber mosaic virus (CMV) strain [24].
  • The dominant locus, RCY1, in the Arabidopsis thaliana ecotype C24 confers resistance to the yellow strain of cucumber mosaic virus (CMV-Y) [25].
  • The 2b protein of cucumoviruses has a role in promoting the cell-to-cell movement of pseudorecombinant viruses [26].


  1. Coordinate regulation of the tryptophan biosynthetic pathway and indolic phytoalexin accumulation in Arabidopsis. Zhao, J., Last, R.L. Plant Cell (1996) [Pubmed]
  2. Salicylic acid has cell-specific effects on tobacco mosaic virus replication and cell-to-cell movement. Murphy, A.M., Carr, J.P. Plant Physiol. (2002) [Pubmed]
  3. Movement of plant viruses is delayed in a beta-1,3-glucanase-deficient mutant showing a reduced plasmodesmatal size exclusion limit and enhanced callose deposition. Iglesias, V.A., Meins, F. Plant J. (2000) [Pubmed]
  4. Identification of epitopes in cucumber mosaic virus using a phage-displayed random peptide library. He, X., Liu, S., Perry, K.L. J. Gen. Virol. (1998) [Pubmed]
  5. Development of a candidate vaccine for Newcastle disease virus by epitope display in the Cucumber mosaic virus capsid protein. Zhao, Y., Hammond, R.W. Biotechnol. Lett. (2005) [Pubmed]
  6. Viral RNA as a potential target for two independent mechanisms of replicase-mediated resistance against cucumber mosaic virus. Hellwald, K.H., Palukaitis, P. Cell (1995) [Pubmed]
  7. Complete replication of a eukaryotic virus RNA in vitro by a purified RNA-dependent RNA polymerase. Hayes, R.J., Buck, K.W. Cell (1990) [Pubmed]
  8. A viral protein inhibits the long range signaling activity of the gene silencing signal. Guo, H.S., Ding, S.W. EMBO J. (2002) [Pubmed]
  9. Plasmodesma-mediated selective protein traffic between "symplasmically isolated" cells probed by a viral movement protein. Itaya, A., Ma, F., Qi, Y., Matsuda, Y., Zhu, Y., Liang, G., Ding, B. Plant Cell (2002) [Pubmed]
  10. Viral RNA trafficking is inhibited in replicase-mediated resistant transgenic tobacco plants. Nguyen, L., Lucas, W.J., Ding, B., Zaitlin, M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  11. Nucleotide sequence of the satellite of peanut stunt virus reveals structural homologies with viroids and certain nuclear and mitochondrial introns. Collmer, C.W., Hadidi, A., Kaper, J.M. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  12. Lupinus albus L. pathogenesis-related proteins that show similarity to PR-10 proteins. Pinto, M.P., Ricardo, C.P. Plant Physiol. (1995) [Pubmed]
  13. Deletions in the conserved amino-terminal basic arm of cucumber mosaic virus coat protein disrupt virion assembly but do not abolish infectivity and cell-to-cell movement. Schmitz, I., Rao, A.L. Virology (1998) [Pubmed]
  14. The structure of tomato aspermy virus by X-ray crystallography. Lucas, R.W., Larson, S.B., Canady, M.A., McPherson, A. J. Struct. Biol. (2002) [Pubmed]
  15. Separation of the complementary strands of double-stranded cucumber mosaic virus-associated RNA 5 and peanut stunt virus-associated RNA 5. Kaper, J.M., Tousignant, M.E. Biochem. Biophys. Res. Commun. (1983) [Pubmed]
  16. Suppression of post-transcriptional gene silencing by a plant viral protein localized in the nucleus. Lucy, A.P., Guo, H.S., Li, W.X., Ding, S.W. EMBO J. (2000) [Pubmed]
  17. Phosphorylation of cucumber mosaic virus RNA polymerase 2a protein inhibits formation of replicase complex. Kim, S.H., Palukaitis, P., Park, Y.I. EMBO J. (2002) [Pubmed]
  18. Transgene translatability increases effectiveness of replicase-mediated resistance to cucumber mosaic virus. Wintermantel, W.M., Zaitlin, M. J. Gen. Virol. (2000) [Pubmed]
  19. The suppressor of transgene RNA silencing encoded by Cucumber mosaic virus interferes with salicylic acid-mediated virus resistance. Ji, L.H., Ding, S.W. Mol. Plant Microbe Interact. (2001) [Pubmed]
  20. Tobamoviral movement protein transiently expressed in a single epidermal cell functions beyond multiple plasmodesmata and spreads multicellularly in an infection-coupled manner. Tamai, A., Meshi, T. Mol. Plant Microbe Interact. (2001) [Pubmed]
  21. Dissecting RNA silencing in protoplasts uncovers novel effects of viral suppressors on the silencing pathway at the cellular level. Qi, Y., Zhong, X., Itaya, A., Ding, B. Nucleic Acids Res. (2004) [Pubmed]
  22. Cucumber mosaic virus 2a polymerase and 3a movement proteins independently affect both virus movement and the timing of symptom development in zucchini squash. Choi, S.K., Palukaitis, P., Min, B.E., Lee, M.Y., Choi, J.K., Ryu, K.H. J. Gen. Virol. (2005) [Pubmed]
  23. The C-terminal 33 amino acids of the cucumber mosaic virus 3a protein affect virus movement, RNA binding and inhibition of infection and translation. Kim, S.H., Kalinina, N.O., Andreev, I., Ryabov, E.V., Fitzgerald, A.G., Taliansky, M.E., Palukaitis, P. J. Gen. Virol. (2004) [Pubmed]
  24. Up-regulation of Arabidopsis thaliana NHL10 in the hypersensitive response to Cucumber mosaic virus infection and in senescing leaves is controlled by signalling pathways that differ in salicylate involvement. Zheng, M.S., Takahashi, H., Miyazaki, A., Hamamoto, H., Shah, J., Yamaguchi, I., Kusano, T. Planta (2004) [Pubmed]
  25. RCY1, an Arabidopsis thaliana RPP8/HRT family resistance gene, conferring resistance to cucumber mosaic virus requires salicylic acid, ethylene and a novel signal transduction mechanism. Takahashi, H., Miller, J., Nozaki, Y., Takeda, M., Shah, J., Hase, S., Ikegami, M., Ehara, Y., Dinesh-Kumar, S.P. Plant J. (2002) [Pubmed]
  26. The 2b protein of cucumoviruses has a role in promoting the cell-to-cell movement of pseudorecombinant viruses. Shi, B.J., Miller, J., Symons, R.H., Palukaitis, P. Mol. Plant Microbe Interact. (2003) [Pubmed]
WikiGenes - Universities