Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

TK - major capsid protein

Lymphocystis disease virus 1

Do, J.W. et al., Zhang, Q.Y. et al., Schnitzler, P. et al., Tidona, C.A. et al., Kitamura, S. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of TK

The deduced amino acid sequence of the major capsid protein (MCP) presents the highest identity to those of LCDV-1 and other iridoviruses among the LCDV-C gene products [1].
The major structural component of the non-enveloped icosahedral virus particles is the major capsid protein (MCP) which appears to be highly conserved among members of the family Iridoviridae, Phycodnaviridae, and African swine fever virus [2].

High impact information on TK

The PCR products were used as hybridization probes for screening the gene library of FLCDV-f. The MCP gene of FLCDV-f(1377 bp; 459 aa; 51.4K) was identified within the DNA sequence of the EcoRI FLCDV-f DNA fragment C (11.2 kbp; 0.611 to 0.718 map units) [3].
Phylogenetic analyses based on the MCP gene showed that SB98Yosu belongs to genotype II, along with Japanese flounder isolates [4].

Biological context of TK

Furthermore, a phylogenetic tree was constructed based on the multiple alignments of nine MCP amino acid sequences [1].
In 2003, 13 isolates of iridovirus were obtained from cultured flounders Paralichthys olivaceus during epizootics in Korea. The full open reading frames (ORFs) encoding the major capsid protein (MCP) (1362 bp) from the 13 flounder iridoviruses (FLIVs) were sequenced and the deduced amino acid sequences were phylogenetically analyzed [5].

References

Complete genome sequence of lymphocystis disease virus isolated from China. Zhang, Q.Y., Xiao, F., Xie, J., Li, Z.Q., Gui, J.F. J. Virol. (2004) [Pubmed]
Is the major capsid protein of iridoviruses a suitable target for the study of viral evolution? Tidona, C.A., Schnitzler, P., Kehm, R., Darai, G. Virus Genes (1998) [Pubmed]
Identification of the gene encoding the major capsid protein of fish lymphocystis disease virus. Schnitzler, P., Darai, G. J. Gen. Virol. (1993) [Pubmed]
Differentiation of lymphocystis disease virus genotype by multiplex PCR. Kitamura, S., Jung, S.J., Oh, M.J. J. Microbiol. (2006) [Pubmed]
Phylogenetic analysis of the major capsid protein gene of iridovirus isolates from cultured flounders Paralichthys olivaceus in Korea. Do, J.W., Cha, S.J., Kim, J.S., An, E.J., Lee, N.S., Choi, H.J., Lee, C.H., Park, M.S., Kim, J.W., Kim, Y.C., Park, J.W. Dis. Aquat. Org. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg