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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

African Swine Fever


Disease relevance of African Swine Fever


High impact information on African Swine Fever


Chemical compound and disease context of African Swine Fever


Biological context of African Swine Fever


Anatomical context of African Swine Fever


Gene context of African Swine Fever


Analytical, diagnostic and therapeutic context of African Swine Fever

  • Sequence analysis of the right variable genomic region of the pathogenic African swine fever virus (ASFV) isolate E70 revealed a novel gene, UK, that is immediately upstream from the previously described ASFV virulence-associated gene NL-S (L. Zsak, Z. Lu, G. F. Kutish, J. G. Neilan, and D. L. Rock, J. Virol. 70:8865-8871, 1996) [31].
  • These mAbs effectively blocked the mixed lymphocyte reaction and the proliferative response to viral antigens (African swine fever virus) and to staphylococcal enterotoxin B. Therefore, these mAbs can be useful reagents for studying MHC class II molecules of pig and crossreactive species, and the immunological processes where they are involved [32].
  • We have previously presented indirect evidence that both specific immunosuppression and lymphocyte mitogenicity induced in mice by p36, a proteinaceous factor of virulence produced by porcine monocytes infected by African swine fever virus, were consistent with a Th2-driven response [33].
  • Tissues obtained from pigs inoculated with African swine fever virus (ASFV), fixed by vascular perfusion using glutaraldehyde, and embedded in paraffin or araldite were used for an immunohistologic electron microscopic study [34].
  • Virus-specific cellular blastogenesis and interleukin-2 production in swine after recovery from African swine fever [35].


  1. Polyprotein processing in African swine fever virus: a novel gene expression strategy for a DNA virus. Simón-Mateo, C., Andrés, G., Viñuela, E. EMBO J. (1993) [Pubmed]
  2. Inducible gene expression from African swine fever virus recombinants: analysis of the major capsid protein p72. García-Escudero, R., Andrés, G., Almazán, F., Viñuela, E. J. Virol. (1998) [Pubmed]
  3. Orf virus encodes a functional dUTPase gene. Cottone, R., Büttner, M., McInnes, C.J., Wood, A.R., Rziha, H.J. J. Gen. Virol. (2002) [Pubmed]
  4. Sequence and evolutionary relationships of African swine fever virus thymidine kinase. Blasco, R., López-Otín, C., Muñóz, M., Bockamp, E.O., Simón-Mateo, C., Viñuela, E. Virology (1990) [Pubmed]
  5. Functional and immunological properties of the baculovirus-expressed hemagglutinin of African swine fever virus. Ruiz-Gonzalvo, F., Rodríguez, F., Escribano, J.M. Virology (1996) [Pubmed]
  6. A ubiquitin conjugating enzyme encoded by African swine fever virus. Hingamp, P.M., Arnold, J.E., Mayer, R.J., Dixon, L.K. EMBO J. (1992) [Pubmed]
  7. Solution structure of a viral DNA polymerase X and evidence for a mutagenic function. Showalter, A.K., Byeon, I.J., Su, M.I., Tsai, M.D. Nat. Struct. Biol. (2001) [Pubmed]
  8. DNA polymerase X of African swine fever virus: insertion fidelity on gapped DNA substrates and AP lyase activity support a role in base excision repair of viral DNA. García-Escudero, R., García-Díaz, M., Salas, M.L., Blanco, L., Salas, J. J. Mol. Biol. (2003) [Pubmed]
  9. African swine fever virus protein pE296R is a DNA repair apurinic/apyrimidinic endonuclease required for virus growth in swine macrophages. Redrejo-Rodríguez, M., García-Escudero, R., Yáñez-Muñoz, R.J., Salas, M.L., Salas, J. J. Virol. (2006) [Pubmed]
  10. Mechanism of inactivation of NF-kappa B by a viral homologue of I kappa b alpha. Signal-induced release of i kappa b alpha results in binding of the viral homologue to NF-kappa B. Tait, S.W., Reid, E.B., Greaves, D.R., Wileman, T.E., Powell, P.P. J. Biol. Chem. (2000) [Pubmed]
  11. The African swine fever virus prenyltransferase is an integral membrane trans-geranylgeranyl-diphosphate synthase. Alejo, A., Andrés, G., Viñuela, E., Salas, M.L. J. Biol. Chem. (1999) [Pubmed]
  12. Genetic identification and nucleotide sequence of the DNA polymerase gene of African swine fever virus. Martins, A., Ribeiro, G., Marques, M.I., Costa, J.V. Nucleic Acids Res. (1994) [Pubmed]
  13. The g5R (D250) gene of African swine fever virus encodes a Nudix hydrolase that preferentially degrades diphosphoinositol polyphosphates. Cartwright, J.L., Safrany, S.T., Dixon, L.K., Darzynkiewicz, E., Stepinski, J., Burke, R., McLennan, A.G. J. Virol. (2002) [Pubmed]
  14. African swine fever virus pB119L protein is a flavin adenine dinucleotide-linked sulfhydryl oxidase. Rodríguez, I., Redrejo-Rodríguez, M., Rodríguez, J.M., Alejo, A., Salas, J., Salas, M.L. J. Virol. (2006) [Pubmed]
  15. Macrophage cytoplasmic vesicle pH gradients and vacuolar H+-ATPase activities relative to virus infection. Natale, V.A., McCullough, K.C. J. Leukoc. Biol. (1998) [Pubmed]
  16. Effect of chloroquine on African swine fever virus infection. Geraldes, A., Valdeira, M.L. J. Gen. Virol. (1985) [Pubmed]
  17. Solution structure of a viral DNA repair polymerase. Maciejewski, M.W., Shin, R., Pan, B., Marintchev, A., Denninger, A., Mullen, M.A., Chen, K., Gryk, M.R., Mullen, G.P. Nat. Struct. Biol. (2001) [Pubmed]
  18. An African swine fever virus ERV1-ALR homologue, 9GL, affects virion maturation and viral growth in macrophages and viral virulence in swine. Lewis, T., Zsak, L., Burrage, T.G., Lu, Z., Kutish, G.F., Neilan, J.G., Rock, D.L. J. Virol. (2000) [Pubmed]
  19. The African swine fever virus thymidine kinase gene is required for efficient replication in swine macrophages and for virulence in swine. Moore, D.M., Zsak, L., Neilan, J.G., Lu, Z., Rock, D.L. J. Virol. (1998) [Pubmed]
  20. Functionality and cell anchorage dependence of the African swine fever virus gene A179L, a viral bcl-2 homolog, in insect cells. Brun, A., Rodríguez, F., Escribano, J.M., Alonso, C. J. Virol. (1998) [Pubmed]
  21. Vimentin rearrangement during African swine fever virus infection involves retrograde transport along microtubules and phosphorylation of vimentin by calcium calmodulin kinase II. Stefanovic, S., Windsor, M., Nagata, K.I., Inagaki, M., Wileman, T. J. Virol. (2005) [Pubmed]
  22. African swine fever virus gene expression in infected Vero cells. Carvalho, Z.G., Rodrigues-Pousada, C. J. Gen. Virol. (1986) [Pubmed]
  23. Role of B and T lymphocytes in the specific immunosuppression induced by a protein released by porcine monocytes infected with African swine fever virus. Ribeiro, A.d.o.s. .S., Arala-Chaves, M.P., Vilanova, M., Porto, M.T., Coutinho, A. Int. Immunol. (1991) [Pubmed]
  24. Granulocyte-macrophage colony stimulating factor promotes prolonged survival and the support of virulent infection by African swine fever virus of macrophages generated from porcine bone marrow and blood. Denham, S., Brookes, S.M., Hutchings, G.H., Parkhouse, R.M. J. Gen. Virol. (1996) [Pubmed]
  25. Interferon-gamma production by African swine fever virus-specific lymphocytes. Revilla, Y., Pena, L., Viñuela, E. Scand. J. Immunol. (1992) [Pubmed]
  26. African swine fever virus encodes a CD2 homolog responsible for the adhesion of erythrocytes to infected cells. Rodríguez, J.M., Yáñez, R.J., Almazán, F., Viñuela, E., Rodriguez, J.F. J. Virol. (1993) [Pubmed]
  27. A conserved African swine fever virus IkappaB homolog, 5EL, is nonessential for growth in vitro and virulence in domestic swine. Neilan, J.G., Lu, Z., Kutish, G.F., Zsak, L., Lewis, T.L., Rock, D.L. Virology (1997) [Pubmed]
  28. Expression and characterization of the thymidine kinase gene of African swine fever virus. Martin Hernandez, A.M., Tabares, E. J. Virol. (1991) [Pubmed]
  29. The DNA polymerase-encoding gene of African swine fever virus: sequence and transcriptional analysis. Rodríguez, J.M., Yáñez, R.J., Rodríguez, J.F., Viñuela, E., Salas, M.L. Gene (1993) [Pubmed]
  30. African swine fever virus guanylyltransferase. Pena, L., Yáñez, R.J., Revilla, Y., Viñuela, E., Salas, M.L. Virology (1993) [Pubmed]
  31. A nonessential African swine fever virus gene UK is a significant virulence determinant in domestic swine. Zsak, L., Caler, E., Lu, Z., Kutish, G.F., Neilan, J.G., Rock, D.L. J. Virol. (1998) [Pubmed]
  32. Characterization of five monoclonal antibodies specific for swine class II major histocompatibility antigens and crossreactivity studies with leukocytes of domestic animals. Bullido, R., Doménech, N., Alvarez, B., Alonso, F., Babín, M., Ezquerra, A., Ortuño, E., Domínguez, J. Dev. Comp. Immunol. (1997) [Pubmed]
  33. The biological effects induced in mice by p36, a proteinaceous factor of virulence produced by African swine fever virus, are mediated by interleukin-4 and also to a lesser extent by interleukin-10. Vilanova, M., Ferreira, P., Ribeiro, A., Arala-Chaves, M. Immunology (1999) [Pubmed]
  34. Detection of African swine fever viral antigens in paraffin-embedded tissues by use of immunohistologic methods and polyclonal antibodies. Fernández, A., Perez, J., Carrasco, L., Sierra, M.A., Sanchez-Vizcaino, M., Jover, A. Am. J. Vet. Res. (1992) [Pubmed]
  35. Virus-specific cellular blastogenesis and interleukin-2 production in swine after recovery from African swine fever. Scholl, T., Lunney, J.K., Mebus, C.A., Duffy, E., Martins, C.L. Am. J. Vet. Res. (1989) [Pubmed]
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