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Disease relevance of Iridovirus

  • The DNA of frog virus 3 (FV3), an iridovirus, is highly methylated; more than 20% of the cytosine bases are methylated at the 5-carbon position by an FV3-induced DNA methyltransferase (DNA-mt) [1].
  • Identification of a Bohle iridovirus thymidine kinase gene and demonstration of activity using vaccinia virus [2].
  • Phylogenetic analysis of the MCP revealed that all 13 FLIVs were the same species as rock bream iridovirus (RBIV), red sea bream iridovirus (RSIV), and infectious spleen and kidney necrosis virus (ISKNV), and were grouped into an unknown genus which was different from the 2 genera known to infect fish, Ranavirus and Lymphocystivirus [3].
  • A phylogenetic analysis of eukaryotic eIF-2alpha and poxvirus and iridovirus eIF-2alpha sequences has demonstrated the relationship of these iridoviruses [4].

High impact information on Iridovirus


Chemical compound and disease context of Iridovirus

  • Fractionations of the iridovirus in a 20-60% sucrose gradient were detected successfully by all the six mAbs using immunodot blot [10].

Biological context of Iridovirus


Gene context of Iridovirus

  • We have cloned and sequenced eIF-2alpha genes of several iridoviruses of fishes and frogs [4].
  • Similar to mammalian Mx, the OsgMx are members of a family of interferon-inducible genes that are expressed by cells in response to nodavirus and iridovirus naturally-infected [13].
  • Using oligonucleotide primers specific for a highly conserved region of the iridovirus major capsid protein, an approximately 500 nucleotide DNA fragment was amplified from SBV and TV2 [14].
  • In situ hybridization of a marine fish virus, Singapore grouper iridovirus with a nucleic acid probe of major capsid protein [15].


  1. Mutation in a DNA-binding protein reveals an association between DNA-methyltransferase activity and a 26,000-Da polypeptide in frog virus 3-infected cells. Essani, K., Goorha, R., Granoff, A. Virology (1987) [Pubmed]
  2. Identification of a Bohle iridovirus thymidine kinase gene and demonstration of activity using vaccinia virus. Coupar, B.E., Goldie, S.G., Hyatt, A.D., Pallister, J.A. Arch. Virol. (2005) [Pubmed]
  3. Phylogenetic analysis of the major capsid protein gene of iridovirus isolates from cultured flounders Paralichthys olivaceus in Korea. Do, J.W., Cha, S.J., Kim, J.S., An, E.J., Lee, N.S., Choi, H.J., Lee, C.H., Park, M.S., Kim, J.W., Kim, Y.C., Park, J.W. Dis. Aquat. Org. (2005) [Pubmed]
  4. Comparison of the eIF-2alpha homologous proteins of seven ranaviruses (Iridoviridae). Essbauer, S., Bremont, M., Ahne, W. Virus Genes (2001) [Pubmed]
  5. Complete genome sequence of lymphocystis disease virus isolated from China. Zhang, Q.Y., Xiao, F., Xie, J., Li, Z.Q., Gui, J.F. J. Virol. (2004) [Pubmed]
  6. Enzyme activities associated with an invertebrate iridovirus: nucleotide phosphohydrolase activity associated with iridescent virus type 6 (CIV). Monnier, C., Devauchelle, G. J. Virol. (1976) [Pubmed]
  7. Identification and characterization of a novel gene of grouper iridovirus encoding a purine nucleoside phosphorylase. Ting, J.W., Wu, M.F., Tsai, C.T., Lin, C.C., Guo, I.C., Chang, C.Y. J. Gen. Virol. (2004) [Pubmed]
  8. Evidence for the evolution of ascoviruses from iridoviruses. Stasiak, K., Renault, S., Demattei, M.V., Bigot, Y., Federici, B.A. J. Gen. Virol. (2003) [Pubmed]
  9. Cloning, sequence analysis, and expression of the major capsid protein of the iridovirus frog virus 3. Mao, J., Tham, T.N., Gentry, G.A., Aubertin, A., Chinchar, V.G. Virology (1996) [Pubmed]
  10. Production and characterization of monoclonal antibodies to a grouper iridovirus. Shi, C., Wei, Q., Gin, K.Y., Lam, T.J. J. Virol. Methods (2003) [Pubmed]
  11. Promoter activity in the 5' flanking regions of the Bohle iridovirus ICP 18, ICP 46 and major capsid protein genes. Pallister, J., Goldie, S., Coupar, B., Hyatt, A. Arch. Virol. (2005) [Pubmed]
  12. Viral DNA sequences of genes encoding the ATPase and the major capsid protein of tropical iridovirus isolates which are pathogenic to fishes in Japan, South China Sea and Southeast Asian countries. Sudthongkong, C., Miyata, M., Miyazaki, T. Arch. Virol. (2002) [Pubmed]
  13. Cloning of an orange-spotted grouper (Epinephelus coioides) Mx cDNA and characterisation of its expression in response to nodavirus. Chen, Y.M., Su, Y.L., Lin, J.H., Yang, H.L., Chen, T.Y. Fish Shellfish Immunol. (2006) [Pubmed]
  14. Molecular characterization of iridoviruses isolated from sympatric amphibians and fish. Mao, J., Green, D.E., Fellers, G., Chinchar, V.G. Virus Res. (1999) [Pubmed]
  15. In situ hybridization of a marine fish virus, Singapore grouper iridovirus with a nucleic acid probe of major capsid protein. Huang, C., Zhang, X., Gin, K.Y., Qin, Q.W. J. Virol. Methods (2004) [Pubmed]
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