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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

H2-Oa  -  histocompatibility 2, O region alpha locus

Mus musculus

Synonyms: H-2Oa
 
 
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High impact information on H2-Oa

  • In nonprofessional APCs, e.g., L929 fibroblasts, IFN-gamma-inducible expression of the MHC class II-specific transcription factor CIITA is associated with coordinate expression of MHCII, Ii, H2-M, and H2-Oa genes but without concomitant H2-Ob induction [1].
  • Mouse HLA-DPA homologue H2-Pa: a pseudogene that maps between H2-Pb and H2-Oa [2].
 

Anatomical context of H2-Oa

  • Recently, the H2-O heterodimer, encoded by H2-Oa and H2-Ob in the MHC class II region, has been shown to be physically associated with H2-M in B cells and to downregulate H2-M function [1].
 

Other interactions of H2-Oa

  • Examination of H2-O expression in freshly isolated mouse organs revealed that H2-Oa- and H2-Ob-specific transcripts are present in both lymphoid and nonlymphoid tissues [1].

References

  1. H2-M, a facilitator of MHC class II peptide loading, and its negative modulator H2-O are differentially expressed in response to proinflammatory cytokines. Walter, W., Scheuer, C., Lingnau, K., Reichert, T.E., Schmitt, E., Loos, M., Maeurer, M.J. Immunogenetics (2000) [Pubmed]
  2. Mouse HLA-DPA homologue H2-Pa: a pseudogene that maps between H2-Pb and H2-Oa. Arimura, Y., Koda, T., Kishi, M., Kakinuma, M. Immunogenetics (1996) [Pubmed]
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